Evidence map›Paper›PMID 39092681›Full record

ArticleThe Laryngoscope2024

Laryngeal Vibrotactile Stimulation Is Feasible, Acceptable To People With Unexplained Chronic Cough.

Stephanie Misono, Erin Y Shen, Anna G Sombrio, Scott Lunos, Jiapeng Xu, Jesse Hoffmeister, Ali Stockness, Lisa Butcher, Daniel Weinstein, Nathaniel T Gaeckle and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stephanie MisonoDepartment of OtoHNS, University of Minnesota, Minneapolis, Minnesota, U.S.A.ORCID 0000-0001-9000-6323
Erin Y ShenUniversity of Minnesota Medical School, Minneapolis, Minnesota, U.S.A.
Anna G SombrioAssociation of Pediatric Program Directors, McLean, Virginia, U.S.A.
Scott LunosBiostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Jiapeng XuSchool of Kinesiology, Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Jesse HoffmeisterDepartment of OtoHNS, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Ali StocknessDepartment of OtoHNS, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Lisa ButcherDepartment of OtoHNS, University of Minnesota, Lions Voice Clinic, Minneapolis, Minnesota, U.S.A.
Daniel WeinsteinDepartment of OtoHNS, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Nathaniel T GaeckleDivision of Pulmonary, Allergy, Critical Care and Sleep, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Raluca GrayDepartment of OtoHNS, University of Minnesota, Minneapolis, Minnesota, U.S.A.ORCID 0000-0003-3403-2345
Jürgen KonczakSchool of Kinesiology, Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, Minnesota, U.S.A.ORCID 0000-0002-4422-5610

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
CTSA K12 Program at University of MinnesotaK12TR004373 · NCATS · UNIVERSITY OF MINNESOTA · PI David H Ingbar · 2024 to 2026
$3.2M
Psychological factors influencing voice outcomes: Technology-based assessment and interventionK23DC016335 · NIDCD · UNIVERSITY OF MINNESOTA · PI MISONO, STEPHANIE · 2017 to 2021
$1.0M
Laryngeal vibration as a non-invasive treatment for spasmodic dysphoniaR01DC016315 · NIDCD · UNIVERSITY OF MINNESOTA · PI KONCZAK, JUERGEN · 2018 to 2020
$775k
American College of Surgeons and the Triological SocietyCSR NIH HHS K23DC016335CSR NIH HHS R01DC016315CSR NIH HHS UL1TR002494NCATS NIH HHS K12 TR004373NCATS NIH HHS UL1 TR002494NCATS NIH HHS UM1 TR004405NIDCD NIH HHS K23 DC016335NIDCD NIH HHS R01 DC016315NIH HHSPediatric Device Innovation Consortium at the University of Minnesota
6 · The paper itself

Abstract

objectivesUnexplained chronic cough (UCC) is common and has significant impacts on quality of life. Ongoing cough can sensitize the larynx, increasing the urge to cough and perpetuating the cycle of chronic cough. Vibrotactile stimulation (VTS) of the larynx is a noninvasive stimulation technique that can modulate laryngeal somatosensory and motor activity. Study objectives were to assess feasibility and acceptability of VTS use by people with UCC. Secondarily, changes in cough-related quality of life measures were assessed.

methodsAdults with UCC recorded cough measures at baseline and after completing 2 weeks of daily VTS. Feasibility and acceptability were assessed through participant-reported device use and structured feedback. Cough-related quality of life measures were the Leicester Cough Questionnaire (LCQ) and the Newcastle Laryngeal Hypersensitivity Questionnaire (NLHQ).

resultsNineteen adults participated, with mean age 67 years and cough duration 130 months. Notably, 93% of planned VTS sessions were logged, 94% of participants found the device comfortable to wear, 89% found it easy to operate and 79% would recommend it to others. Pre-post LCQ change achieved a minimal important difference (MID) (mean 1.3 [SD 2.4, p = 0.015]). NLHQ scores improved, but did not reach an MID.

conclusionsLaryngeal VTS use was feasible and acceptable for use by patients with UCC and was associated with a meaningful improvement in cough-related quality of life. Future studies will include VTS dose refinement and the inclusion of a comparison arm to further assess the potential for laryngeal VTS as a novel treatment modality for UCC. LEVEL OF EVIDENCE: 4 Laryngoscope, 134:5010-5014, 2024.

Indexed as

CoughFeasibility StudiesLarynxQuality of LifeAdultAgedAged, 80 and overChronic CoughChronic DiseaseFemaleHumansMaleMiddle AgedPhysical StimulationSurveys and QuestionnairesTreatment Outcomechronic coughquality of lifevibrotactile stimulation

Identifiers

PMID39092681
PMCPMC11563899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.