Evidence map›Paper›PMID 39092127›Full record

ArticleChemical science2024

Negative cooperativity in the formation of H-bond networks involving primary anilines.

Fergal E Hanna, Alexander J Root, Markus Schade, Christopher A Hunter

Abstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fergal E HannaYusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK herchlsmith.orgchem@ch.cam.ac.uk.ORCID https://orcid.org/0000-0002-9376-9921
Alexander J RootYusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK herchlsmith.orgchem@ch.cam.ac.uk.ORCID https://orcid.org/0009-0008-0432-6901
Markus SchadeChemistry, Oncology R&D, AstraZeneca 1 Francis Crick Avenue Cambridge CB2 0AA UK.ORCID https://orcid.org/0000-0002-5538-5767
Christopher A HunterYusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK herchlsmith.orgchem@ch.cam.ac.uk.ORCID https://orcid.org/0000-0002-5182-1859

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Networks of H-bonds can show non-additive behaviour, where the strength of one interaction perturbs another. The magnitude of such cooperative effects can be quantified by measuring the effect of the presence of an intramolecular H-bond at one site on a molecule on the association constant for formation of an intermolecular H-bond at another site. This approach has been used to quantify the cooperativity associated with the interaction of a primary amine with two H-bond acceptors. A series of compounds that have an intramolecular H-bond between an aniline NH

Identifiers

PMID39092127
PMCPMC11290332

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.