Evidence map›Paper›PMID 39092080›Full record

ArticleBiochemical engineering journal2024

Evaluation of the efficiency of various methods to load fluoroquinolones into

Meishan Wu, Lauryn Holgado, Rachael M Harrower, Angela C Brown

Abstract read
In one paragraph

Article in Biochemical engineering journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meishan WuDepartment of Chemical and Biomolecular Engineering, Lehigh University, 124 E. Morton St., Bethlehem, PA, 18015, USA.
Lauryn HolgadoDepartment of Chemical and Biomolecular Engineering, Lehigh University, 124 E. Morton St., Bethlehem, PA, 18015, USA.
Rachael M HarrowerDepartment of Biological Sciences, Lehigh University, 111 Research Dr., Bethlehem, PA, 18015, USA.
Angela C BrownDepartment of Chemical and Biomolecular Engineering, Lehigh University, 124 E. Morton St., Bethlehem, PA, 18015, USA.

Funding

Elucidating the membrane properties regulating antimicrobial peptidebinding to bacterial vesiclesR15GM152918 · NIGMS · LEHIGH UNIVERSITY · PI WITTENBERG, NATHAN J. · 2023 to 2023
$457k
Controlled antibiotic delivery vehicle for treatment of aggressiveperiodontitisR21DE032153 · NIDCR · LEHIGH UNIVERSITY · PI BROWN, ANGELA C. · 2023 to 2024
$408k
NIDCR NIH HHS R21 DE032153NIGMS NIH HHS R15 GM152918
6 · The paper itself

Abstract

The development of novel antibacterial agents that are effective against Gram-negative bacteria is limited primarily by transport issues. This class of bacteria maintains a complex cell envelope consisting of two membrane bilayers, preventing the passage of most antibiotics. These drugs must therefore pass through protein channels called porins; however, many antibiotics are too large to pass through porins, and a common mechanism of acquired resistance is down-regulation of porins. To overcome this transport limitation, we have proposed the use of outer membrane vesicles (OMVs), released by Gram-negative bacteria, which deliver cargo to other bacterial cells in a porin-independent manner. In this work, we systematically studied the ability to load fluoroquinolones into purified

Indexed as

antibiotic resistancefluoroquinolonesGram-negative bacteriaOuter membrane vesicles

Identifiers

PMID39092080
PMCPMC11290469

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.