Evidence map›Paper›PMID 39091978›Full record

ArticleFrontiers in neurology2024

Usefulness of cerebrospinal fluid presepsin (soluble CD14 subtype) as a new marker in the diagnosis of neurosurgical postoperative meningitis.

Yutaka Fuchinoue, Kosuke Kondo, Yuki Sakaeyama, Chie Nakada, Sayaka Terazono, Syuhei Kubota, Masataka Mikai, Mituyoshi Abe, Shinji Ujiie, Toshisuke Morita and 1 more

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Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yutaka FuchinoueDepartment of Neurosurgery (Omori), Faculty of Medicine, Toho University, Tokyo, Japan.
Kosuke KondoDepartment of Neurosurgery (Omori), Faculty of Medicine, Toho University, Tokyo, Japan.
Yuki SakaeyamaDepartment of Neurosurgery (Omori), Faculty of Medicine, Toho University, Tokyo, Japan.
Chie NakadaDepartment of Neurosurgery (Omori), Faculty of Medicine, Toho University, Tokyo, Japan.
Sayaka TerazonoDepartment of Neurosurgery (Omori), Faculty of Medicine, Toho University, Tokyo, Japan.
Syuhei KubotaDepartment of Neurosurgery (Omori), Faculty of Medicine, Toho University, Tokyo, Japan.
Masataka MikaiDepartment of Neurosurgery (Omori), Faculty of Medicine, Toho University, Tokyo, Japan.
Mituyoshi AbeDepartment of Neurosurgery (Omori), Faculty of Medicine, Toho University, Tokyo, Japan.
Shinji UjiieDepartment of Laboratory Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
Toshisuke MoritaDepartment of Laboratory Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
Nobuo SugoDepartment of Neurosurgery (Omori), Faculty of Medicine, Toho University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To determine the usefulness of cerebrospinal fluid (CSF) presepsin in the diagnosis of neurosurgical postoperative meningitis (POM). Methods: The study included patients admitted to the Department of Neurosurgery, Toho University Medical Center Omori Hospital from May 1, 2020 to March 31, 2022 with suspected meningitis after neurosurgery who clinically required CSF sampling and patients who underwent CSF sampling for examination of idiopathic normal pressure hydrocephalus (iNPH). Participants were divided into a POM and a postoperative non meningitis (PONM) group based on the POM diagnostic criteria established for this study. The control group included patients from whom a CSF sample for iNPH was collected by tap test. Results: A total of 238 CSF samples were collected from 90 patients. There were 39 samples in the POM, 180 samples in the PONM, and 19 samples in the control group. CSF presepsin levels in the POM were significantly higher than in the PONM group (1764.5 and 440.9 pg./mL, respectively; Conclusion: CSF presepsin is a useful marker in the diagnosis of neurosurgical POM even in patients with blood components, such as SAH. When POM is suspected, measurement of CSF presepsin may be recommended in addition to a general CSF examination.

Indexed as

CSF presepsinmeningitisneurosurgical postoperative meningitispostoperative meningitispresepsinsoluble CD14 subtype

Identifiers

PMID39091978
PMCPMC11291375

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