Evidence map›Paper›PMID 39091879›Full record

ArticlebioRxiv : the preprint server for biology2024

Genetic variants affect diurnal glucose levels throughout the day.

Nasa Sinnott-Armstrong, Satu Strausz, Lea Urpa, Erik Abner, Jesse Valliere, Estonian Biobank Research Team, Priit Palta, Hassan S Dashti, Mark Daly, Jonathan K Pritchard and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Nasa Sinnott-ArmstrongHerbold Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-4490-0601
Satu StrauszInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-6778-4848
Lea UrpaInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-8712-3518
Erik AbnerEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-6529-3161
Jesse ValliereBroad Institute of Harvard and MIT and Center of Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Estonian Biobank Research Team
Priit PaltaEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0001-9320-7008
Hassan S DashtiBroad Institute of Harvard and MIT and Center of Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-1650-679X
Mark DalyInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0949-8752
Jonathan K PritchardDepartment of Genetics, Stanford University, CA, USA.ORCID 0000-0002-8828-5236
Richa SaxenaBroad Institute of Harvard and MIT and Center of Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2233-1065
Samuel E JonesInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
Hanna M OllilaInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-5302-6429

Funding

Technology to understand genetic variant effects in contextRM1HG010461 · NHGRI · UNIVERSITY OF WASHINGTON · PI Douglas M Fowler, Bruce Colston Trapnell · 2019 to 2026
$18.9M
NHGRI NIH HHS RM1 HG010461Wellcome Trust
6 · The paper itself

Abstract

Circadian rhythms not only coordinate the timing of wake and sleep but also regulate homeostasis within the body, including glucose metabolism. However, the genetic variants that contribute to temporal control of glucose levels have not been previously examined. Using data from 420,000 individuals from the UK Biobank and replicating our findings in 100,000 individuals from the Estonian Biobank, we show that diurnal serum glucose is under genetic control. We discover a robust temporal association of glucose levels at the Melatonin receptor 1B (

Identifiers

PMID39091879
PMCPMC11291026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.