Evidence map›Paper›PMID 39091865›Full record

ArticlebioRxiv : the preprint server for biology2024

Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins.

Nathan A Gillespie, Michael C Neale, Matthew S Panizzon, Ruth E McKenzie, Xin M Tu, Hong Xian, Chandra A Reynolds, Michael J Lyons, Robert A Rissman, Jeremy A Elman and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Nathan A GillespieVirginia Institute for Psychiatric and Behaviour Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0001-8655-2823
Michael C NealeVirginia Institute for Psychiatric and Behaviour Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Matthew S PanizzonDepartment of Psychiatry, University of California, San Diego, La Jolla CA, USA.
Ruth E McKenzieDepartment of Psychology, Boston University, Boston MA, USA.
Xin M TuCenter for Behavior Genetics of Aging, University of California, San Diego, La Jolla CA, USA.
Hong XianDepartment of Epidemiology and Biostatistics, Saint Louis University, St. Louis MO, USA.
Chandra A ReynoldsInstitute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado, Boulder, Boulder, CO USA.
Michael J LyonsDepartment of Psychological and Brain Sciences, Boston University, Boston MA, USA.
Robert A RissmanDepartment of Psychiatry, University of California, San Diego, La Jolla CA, USA.ORCID 0000-0001-9245-8278
Jeremy A ElmanDepartment of Psychiatry, University of California, San Diego, La Jolla CA, USA.
Carol FranzDepartment of Psychiatry, University of California, San Diego, La Jolla CA, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, La Jolla CA, USA.

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, CALEB E · 2018 to 2022
$11.5M
SDSU ADAR ProgramR25AG043364 · NIA · SAN DIEGO STATE UNIVERSITY · PI THEREASA A CRONAN · 2013 to 2026
$5.5M
Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2M
Moderate alcohol use: risk or protective factor for age-related cognitive decline, mild cognitive impairment, and brain health in agingR01AG062483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCEVOY, LINDA KATHLEEN · 2019 to 2021
$1.6M
Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR56AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2016 to 2016
$818k
Linking genetic subtypes of Alzheimer's disease to biological and cognitive heterogeneityK01AG063805 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A · 2021 to 2024
$516k
Practice Effects in Cognitive Aging: Implications for Biomarkers and Early DiagnosisF31AG064834 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDERSON-CIMINO, MARK · 2020 to 2021
$78k
NIA NIH HHS F31 AG064834NIA NIH HHS K01 AG063805NIA NIH HHS P01 AG055367NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG062483NIA NIH HHS R25 AG043364NIA NIH HHS R56 AG037985
6 · The paper itself

Abstract

introductionThe amyloid cascade hypothesis predicts that amyloid-beta (Aβ) aggregation drives tau tangle accumulation. We tested competing causal and non-causal hypotheses regarding the direction of causation between Aβ40 and Aβ42 and total Tau (t-Tau) plasma biomarkers.

methodsPlasma Aβ40, Aβ42, t-Tau, and neurofilament light chain (NFL) were measured in 1,035 men (mean = 67.0 years) using Simoa immunoassays. Genetically informative twin modeling tested the direction of causation between Aβs and t-Tau.

resultsNo clear evidence that Aβ40 or Aβ42 directly causes changes in t-Tau was observed; the alternative causal hypotheses also fit the data well. In contrast, exploratory analyses suggested a causal impact of the Aβ biomarkers on NFL. Separately, reciprocal causation was observed between t-Tau and NFL. DISCUSSION: Plasma Aβ40 or Aβ42 do not appear to have a direct causal impact on t-Tau. In contrast, Aβ aggregation may causally impact NFL in cognitively unimpaired men in their late 60s.

Indexed as

amyloid-betaCascade hypothesisdirection of causationgenetautwin

Identifiers

PMID39091865
PMCPMC11291022

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.