Evidence map›Paper›PMID 39091853›Full record

ArticlebioRxiv : the preprint server for biology2024

Utilization of a Human Liver Tissue Chip for Drug-Metabolizing Enzyme Induction Studies of Perpetrator and Victim Drugs.

Shivam Ohri, Paarth Parekh, Lauren Nichols, Shiny Amala Priya Rajan, Murat Cirit

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Shivam OhriJavelin Biotech, Inc., 299 Washington Street, Woburn, Massachusetts 01801, USA.
Paarth ParekhJavelin Biotech, Inc., 299 Washington Street, Woburn, Massachusetts 01801, USA.
Lauren NicholsJavelin Biotech, Inc., 299 Washington Street, Woburn, Massachusetts 01801, USA.
Shiny Amala Priya RajanJavelin Biotech, Inc., 299 Washington Street, Woburn, Massachusetts 01801, USA.
Murat CiritJavelin Biotech, Inc., 299 Washington Street, Woburn, Massachusetts 01801, USA.

Funding

Hepatic Clearance Chip for PharmacokineticsR44TR004524 · NCATS · JAVELIN BIOTECH · PI CIRIT, MURAT · 2023 to 2024
$2.0M
DDI-on-a-chip: an optimized liver microphysiological system and microenvironment for complex drug-drug interaction studiesR43GM143980 · NIGMS · JAVELIN BIOTECH · PI CIRIT, MURAT · 2021 to 2021
$260k
NCATS NIH HHS R44 TR004524NIGMS NIH HHS R43 GM143980
6 · The paper itself

Abstract

Polypharmacy-related drug-drug interactions (DDIs) are a significant and growing healthcare concern. Increasing number of therapeutic drugs on the market underscores the necessity to accurately assess the new drug combinations during pre-clinical evaluation for DDIs.

Identifiers

PMID39091853
PMCPMC11291003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.