Evidence map›Paper›PMID 39091832›Full record

ArticlebioRxiv : the preprint server for biology2024

Therapeutic DBS for OCD Suppresses the Default Mode Network.

Natalya Slepneva, Genevieve Basich-Pease, Lee Reid, Adam C Frank, Tenzin Norbu, Andrew D Krystal, Leo P Sugrue, Julian C Motzkin, Paul S Larson, Philip A Starr and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Natalya SlepnevaWeill Institute for Neurosciences, University of California, San Francisco.
Genevieve Basich-PeaseWeill Institute for Neurosciences, University of California, San Francisco.
Lee ReidDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco.
Adam C FrankDepartment of Psychiatry and Behavioral Sciences, Keck School of Medicine of USC.
Tenzin NorbuWeill Institute for Neurosciences, University of California, San Francisco.
Andrew D KrystalWeill Institute for Neurosciences, University of California, San Francisco.
Leo P SugrueWeill Institute for Neurosciences, University of California, San Francisco.
Julian C MotzkinWeill Institute for Neurosciences, University of California, San Francisco.
Paul S LarsonDepartment of Neurosurgery, University of Arizona.
Philip A StarrWeill Institute for Neurosciences, University of California, San Francisco.
Melanie A MorrisonWeill Institute for Neurosciences, University of California, San Francisco.
A Moses LeeWeill Institute for Neurosciences, University of California, San Francisco.

Funding

Direct Intracranial Electrophysiological Mapping of Insular Circuits for Anxiety in the Human BrainK23MH125018 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, ANDREW MOSES · 2021 to 2025
$1.0M
Targeting DBS Therapy to the OCD Network Using fMRI and Intracranial RecordingsR21MH130914 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, ANDREW MOSES, MORRISON, MELANIE A · 2022 to 2023
$444k
NIMH NIH HHS K23 MH125018NIMH NIH HHS R21 MH130914
6 · The paper itself

Abstract

Background: Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is an emerging treatment for severe, refractory obsessive-compulsive disorder (OCD). The therapeutic effects of DBS are hypothesized to be mediated by direct modulation of a distributed cortico-striato-thalmo-cortical network underlying OCD symptoms. However, the exact underlying mechanism by which DBS exerts its therapeutic effects still remains unclear. Method: In five participants receiving DBS for severe, refractory OCD (3 responders, 2 non-responders), we conducted a DBS On/Off cycling paradigm during the acquisition of functional MRI to determine the network effects of stimulation across a variety of bipolar configurations. We also performed tractography using diffusion-weighted imaging (DWI) to relate the functional impact of DBS to the underlying structural connectivity between active stimulation contacts and functional brain networks. Results: We found that therapeutic DBS had a distributed effect, suppressing BOLD activity within regions such as the orbitofrontal cortex, dorsomedial prefrontal cortex, and subthalamic nuclei compared to non-therapeutic configurations. Many of the regions suppressed by therapeutic DBS were components of the default mode network (DMN). Moreover, the estimated stimulation field from the therapeutic configurations exhibited significant structural connectivity to core nodes of the DMN. Conclusions: Therapeutic DBS for OCD suppresses BOLD activity within a distributed set of regions within the DMN relative to non-therapeutic configurations. We propose that these effects may be mediated by interruption of communication through structural white matter connections surrounding the DBS active contacts.

Indexed as

Anterior Limb of the Internal CapsuleDeep Brain StimulationDefault Mode NetworkDTIfMRIOCDtractography

Identifiers

PMID39091832
PMCPMC11291060

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.