Evidence map›Paper›PMID 39091808›Full record

ArticlebioRxiv : the preprint server for biology2024

Return of intracranial beta oscillations and traveling waves with recovery from traumatic brain injury.

Alex Vaz, Connor Wathen, Stephen Miranda, Rachel Thomas, Timothy Darlington, Rashad Jabarkheel, Samuel Tomlinson, John Arena, Kamila Bond, Sanjana Salwi and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Alex VazDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0001-8820-7927
Connor WathenDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Stephen MirandaDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Rachel ThomasDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Timothy DarlingtonDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Rashad JabarkheelDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Samuel TomlinsonDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
John ArenaDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kamila BondDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Sanjana SalwiDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Sonia AjmeraDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ludovica Bachschmid-RomanoInstitute of Neurobiology of the Mediterranean, INMED, Aix Marseille University, Marseille, France.
James GuggerDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Danielle SandsmarkDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
James SchusterDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ashwin G RamayyaDepartment of Neurosurgery, Stanford University, Palo Alto, CA, 94305, USA.
Iahn CajigasDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Bijan PesaranDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
H Isaac ChenDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Dmitriy PetrovDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Funding

Neurosurgeon Research Career Development Program (NRCDP)K12NS129164 · NINDS · WASHINGTON UNIVERSITY · PI Sepideh Amin-Hanjani, Emad N Eskandar · 2023 to 2026
$6.7M
Neuroimaging Phenotypes of Post-Traumatic EpilepsyK23NS135101 · NINDS · UNIVERSITY OF ROCHESTER · PI James J Gugger · 2024 to 2026
$664k
Investigating ripple oscillations as a mechanism for human memory retrievalF31NS113400 · NINDS · DUKE UNIVERSITY · PI VAZ, ALEX · 2019 to 2020
$80k
NINDS NIH HHS F31 NS113400NINDS NIH HHS K12 NS129164NINDS NIH HHS K23 NS135101
6 · The paper itself

Abstract

Traumatic brain injury (TBI) remains a pervasive clinical problem associated with significant morbidity and mortality. However, TBI remains clinically and biophysically ill-defined, and prognosis remains difficult even with the standardization of clinical guidelines and advent of multimodality monitoring. Here we leverage a unique data set from TBI patients implanted with either intracranial strip electrodes during craniotomy or quad-lumen intracranial bolts with depth electrodes as part of routine clinical practice. By extracting spectral profiles of this data, we found that the presence of narrow-band oscillatory activity in the beta band (12-30 Hz) closely corresponds with the neurological exam as quantified with the standard Glasgow Coma Scale (GCS). Further, beta oscillations were distributed over the cortical surface as traveling waves, and the evolution of these waves corresponded to recovery from coma, consistent with the putative role of waves in perception and cognitive activity. We consequently propose that beta oscillations and traveling waves are potential biomarkers of recovery from TBI. In a broader sense, our findings suggest that emergence from coma results from recovery of thalamo-cortical interactions that coordinate cortical beta rhythms.

Identifiers

PMID39091808
PMCPMC11291083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.