Evidence map›Paper›PMID 39091803›Full record

ArticlebioRxiv : the preprint server for biology2024

Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin.

Carlos R Cortez-Romero, Jixing Lyu, Arvind S Pillai, Arthur Laganowsky, Joseph W Thornton

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Carlos R Cortez-RomeroDepartment of Cell and Molecular Biology, University of Chicago, Chicago, IL, 60637.
Jixing LyuDepartment of Chemistry, Texas A&M University, College Station, TX, 77843.
Arvind S PillaiDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, 60637.
Arthur LaganowskyDepartment of Chemistry, Texas A&M University, College Station, TX, 77843.ORCID 0000-0001-5012-5547
Joseph W ThorntonDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, 60637.ORCID 0000-0001-9589-6994

Funding

Genetic and biophysical causes of historical protein evolutionR35GM145336 · NIGMS · UNIVERSITY OF CHICAGO · PI Joseph W Thornton · 2022 to 2026
$2.6M
Evolution of molecular complexes: genetic, structural, and functional mechanisms for the evolution of oligomers and allosteryR01GM131128 · NIGMS · UNIVERSITY OF CHICAGO · PI THORNTON, JOSEPH W · 2019 to 2021
$904k
NIGMS NIH HHS R01 GM131128NIGMS NIH HHS R35 GM145336
6 · The paper itself

Abstract

Many proteins form paralogous multimers - molecular complexes in which evolutionarily related proteins are arranged into specific quaternary structures. Little is known about the mechanisms by which they acquired their stoichiometry (the number of total subunits in the complex) and heterospecificity (the preference of subunits for their paralogs rather than other copies of the same protein). Here we use ancestral protein reconstruction and biochemical experiments to study historical increases in stoichiometry and specificity during the evolution of vertebrate hemoglobin (Hb), a

Indexed as

evolution of specificitygene duplicationheterodimersisologyMajor classification - Biological SciencesMinor classifications – Biochemistry/Evolutionmolecular complexesmultimeric proteinsprotein evolution

Identifiers

PMID39091803
PMCPMC11291130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.