Evidence map›Paper›PMID 39091794›Full record

ArticlebioRxiv : the preprint server for biology2024

V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging.

Fiza Hashmi, Patricia M Kane

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Fiza HashmiDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY USA.
Patricia M KaneDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY USA.ORCID 0000-0003-4210-1187

Funding

Regulation and Cellular Functions of V-ATPasesR35GM145256 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI PATRICIA M KANE · 2022 to 2026
$2.9M
NIGMS NIH HHS R35 GM145256
6 · The paper itself

Abstract

Declines in lysosomal acidification and function with aging are observed in organisms ranging from yeast to humans. V-ATPases play a central role in organelle acidification and V-ATPase activity is regulated by reversible disassembly in many different settings. Using the yeast

Indexed as

Agingcaloric restrictionlysosomesproton pumpsSaccharomyces cerevisiae

Identifiers

PMID39091794
PMCPMC11291124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.