Evidence map›Paper›PMID 39091782›Full record

ArticlebioRxiv : the preprint server for biology2024

MENTOR: Multiplex Embedding of Networks for Team-Based Omics Research.

Kyle A Sullivan, J Izaak Miller, Alice Townsend, Mallory Morgan, Matthew Lane, Mirko Pavicic, Manesh Shah, Mikaela Cashman, Daniel A Jacobson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyle A SullivanComputational and Predictive Biology, Oak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID 0000-0002-4621-5598
J Izaak MillerOffice of Innovative Technologies, University of Tennessee-Knoxville, Knoxville, TN.ORCID 0000-0002-6114-5401
Alice TownsendBredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee-Knoxville, Knoxville, TN.ORCID 0000-0002-7535-8862
Mallory MorganComputational and Predictive Biology, Oak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID 0000-0002-3309-1813
Matthew LaneBredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee-Knoxville, Knoxville, TN.ORCID 0000-0002-7750-6822
Mirko PavicicComputational and Predictive Biology, Oak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID 0000-0002-2908-3183
Manesh ShahComputational and Predictive Biology, Oak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID 0000-0003-1436-5345
Mikaela CashmanComputational and Predictive Biology, Oak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID 0000-0003-0620-7830
Daniel A JacobsonComputational and Predictive Biology, Oak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID 0000-0002-9822-8251

Funding

Synergy Core (SynC)P50DA054071 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI Vanessa Troiani · 2022 to 2026
$13.1M
Gene Network Identification and Integration (GNetii) Approach to Understanding the Biology Underlying HIV and Drug Abuse.R01DA051908 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JACOBSON, DANIEL A, JOHNSON, ERIC OTTO · 2020 to 2024
$3.4M
Integrating Multiple Omics to Illuminate Gene Networks Underlying Cigarette Smoking and Opioids.R01DA051913 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI HANCOCK, DANA B, JACOBSON, DANIEL A · 2020 to 2024
$2.9M
NIDA NIH HHS P50 DA054071NIDA NIH HHS R01 DA051908NIDA NIH HHS R01 DA051913
6 · The paper itself

Abstract

While the proliferation of data-driven omics technologies has continued to accelerate, methods of identifying relationships among large-scale changes from omics experiments have stagnated. It is therefore imperative to develop methods that can identify key mechanisms among one or more omics experiments in order to advance biological discovery. To solve this problem, here we describe the network-based algorithm MENTOR - Multiplex Embedding of Networks for Team-Based Omics Research. We demonstrate MENTOR's utility as a supervised learning approach to successfully partition a gene set containing multiple ontological functions into their respective functions. Subsequently, we used MENTOR as an unsupervised learning approach to identify important biological functions pertaining to the host genetic architectures in

Identifiers

PMID39091782
PMCPMC11291001

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.