ArticlebioRxiv : the preprint server for biology2024
Daniel Kim, Raymond Fang, Pengpeng Zhang, Cheng Sun, Guorong Li, Christa Montgomery, Simon W M John, W Daniel Stamer, Hao F Zhang, C Ross Ethier
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Daniel KimDepartment of Biomedical Engineering, Northwestern University, Evanston, IL.
Raymond FangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL.
Pengpeng ZhangDepartment of Mechanical Engineering, Northwestern University, Evanston, IL.
Cheng SunDepartment of Mechanical Engineering, Northwestern University, Evanston, IL.
Guorong LiDepartment of Ophthalmology, Duke University, Durham, NC.
Christa MontgomeryDepartment of Ophthalmology, Columbia University Irving Medical Center, and Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY.
Simon W M JohnDepartment of Ophthalmology, Columbia University Irving Medical Center, and Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY.ORCID 0000-0002-4319-0356 W Daniel StamerDepartment of Ophthalmology, Duke University, Durham, NC.
C Ross EthierDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0000-0001-6110-3052 Funding
VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Goldis Malek · 1985 to 2026
$19.3MInstrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9MQuantitative assessment of glaucomatous conventional outflow dynamicsR01EY030124 · NEI · DUKE UNIVERSITY · PI C ROSS ETHIER, Sina Farsiu · 2019 to 2026
$4.0MDoes VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?R01EY032062 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHN, SIMON W, KIZHATIL, KRISHNAKUMAR · 2021 to 2025
$3.5MClinical glaucoma management enabled by visible-light OCTU01EY033001 · NEI · NORTHWESTERN UNIVERSITY · PI SCHUMAN, JOEL S, ZHANG, HAO F · 2021 to 2025
$3.2MIn Vivo Function and Metabolism Evaluation of Glaucomatous RGCs by Two-Photon Scanning Laser OphthalmologyR01EY034353 · NEI · STANFORD UNIVERSITY · PI Yang Hu, Hao F Zhang · 2023 to 2026
$2.7MVisible-light optical coherence tomography for clinical glaucoma managementR44EY026466 · NEI · OPTICENT, INC. · PI KURANOV, ROMAN · 2018 to 2023
$2.7MNovel ocular imaging and molecular analysis of anterior eye segment for glaucomaR01EY034740 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Tsutomu Kume, Hao F Zhang · 2023 to 2026
$2.7MTranscriptional and Biomechanical Analysis of Segmental Outflow in GlaucomaR01EY031710 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ETHIER, C ROSS, GUPTA, DIVAKAR · 2020 to 2023
$2.4MModels, mechanisms and treatment of LMX1B-induced glaucomaR01EY032507 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHN, SIMON W · 2021 to 2024
$2.3MInvestigating nanoscale neuronal damages in early glaucoma towards clinical optical detectionR01EY029121 · NEI · NORTHWESTERN UNIVERSITY · PI LIU, XIAORONG, ZHANG, HAO F · 2018 to 2021
$2.0MA Nanocarrier Platform for Targeting Schlemm's Canal CellsR01EY033813 · NEI · NORTHWESTERN UNIVERSITY · PI JOHNSON, MARK, SCOTT, EVAN ALEXANDER · 2022 to 2025
$1.9MNEI NIH HHS F30 EY034033NEI NIH HHS P30 EY005722NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY029121NEI NIH HHS R01 EY030124NEI NIH HHS R01 EY031710NEI NIH HHS R01 EY032062NEI NIH HHS R01 EY032507NEI NIH HHS R01 EY033813NEI NIH HHS R01 EY034353NEI NIH HHS R01 EY034740NEI NIH HHS R44 EY026466NEI NIH HHS U01 EY033001
6 · The paper itselfAbstract
Purpose: Aqueous humor inflow rate, a key parameter influencing aqueous humor dynamics, is typically measured by fluorophotometery. Analyzing fluorophotometric data depends, Methods: We used standard near-infrared optical coherence tomography (OCT) and robotic visible-light OCT (vis-OCT) to visualize, reconstruct and quantify the volumes of the anterior and posterior chambers of the mouse eye Results: Posterior chamber volume is 1.1 times the anterior chamber volume in BALB/cAnNCrl mice, i.e. the anterior chamber constitutes about 47% of the total aqueous humor volume, which is very dissimilar to the situation in humans. Anterior chamber volumes in 2-month-old BALB/cAnNCrl and 7-month-old C57BL6/J mice were 1.55 ± 0.36 μL (n=10) and 2.41 ± 0.29 μL (n=8), respectively. This implies that previous studies likely over-estimated aqueous inflow rate by approximately two-fold. Conclusions: It is necessary to reassess previously reported estimates of aqueous inflow rates, and thus aqueous humor dynamics in the mouse. For example, we now estimate that only 0-15% of aqueous humor drains via the pressure-independent (unconventional) route, similar to that seen in humans and monkeys.
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PMID39091756
PMCPMC11291131
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