Evidence map›Paper›PMID 39091744›Full record

ArticlebioRxiv : the preprint server for biology2024

A second X chromosome improves cognition in aging male and female mice.

Francesca Marino, Dan Wang, Gennifer E Merrihew, Michael J MacCoss, Dena B Dubal

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesca MarinoDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID 0000-0002-7899-4282
Dan WangDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Gennifer E MerrihewDepartment of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.ORCID 0000-0003-4903-0318
Michael J MacCossDepartment of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.ORCID 0000-0003-1853-0256
Dena B DubalDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-7504-4372

Funding

University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 1995 to 2026
$27.1M
Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2020 to 2024
$15.9M
Collagen VI: Novel Mechanisms and Functions in Alzheimer's DiseaseK08AG034531 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2009 to 2013
$540k
NIA NIH HHS K08 AG034531NIA NIH HHS P30 AG013280NIA NIH HHS U19 AG065156
6 · The paper itself

Abstract

Women show resilience to cognitive aging, in the absence of dementia, in many populations. To dissect sex differences, we utilized the FCG and XY* mouse models. Female gonads and sex chromosomes improved cognition in aging mice of both sexes. Further, presence of a second X in male and female mice conferred cognitive resilience while its absence in females blocked it. In the hippocampal proteome of aging female mice, the second X increased proteins involved in synaptogenesis signaling - a potential pathway to improved cognition.

Identifiers

PMID39091744
PMCPMC11291180

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.