In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Guohua LvDepartment of Biochemistry, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10021, United States.
Nicole M SaylesFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 E 61 Street, New York, NY 10065, United States.
Yun HuangDepartment of Physiology & Biophysics, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10021, United States.ORCID 0000-0002-2991-6122 Chiara D MancinelliDepartment of Biochemistry, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10021, United States.ORCID 0000-0002-2653-4698 Kevin McAvoyFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 E 61 Street, New York, NY 10065, United States.
Neil A ShneiderDepartment of Neurology, Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, 630 W 168 Street, New York, NY 10032.ORCID 0000-0002-3223-7366 Giovanni ManfrediFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 E 61 Street, New York, NY 10065, United States.
Hibiki KawamataFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 E 61 Street, New York, NY 10065, United States.ORCID 0000-0003-0020-6933 David EliezerDepartment of Biochemistry, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10021, United States.ORCID 0000-0002-1311-7537 Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1MSilence ALS: A Platform for the Discovery and Development of Antisense Therapeutics for Patients with Ultra-Rare Forms of ALSU01NS134684 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Neil Alan Shneider · 2024 to 2026
$15.9MMitochondrial Integrated Stress Response in Neurological DiseasesR35NS122209 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Giovanni Manfredi · 2021 to 2026
$6.6MStructure and Function of TauRF1AG066493 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELIEZER, DAVID · 2020 to 2020
$2.4MAcquisition of a Cold Probe and Console for a 600MHz NMR spectrometerS10OD016320 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BRACKEN, WILLIAM C · 2013 to 2013
$600kUpgrade of the RF electronics console and probes for chemical biology.S10OD028556 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BRACKEN, WILLIAM C · 2020 to 2020
$600kIron homeostasis alterations in mutant CHCHD10 mitochondriaF31HL154651 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAYLES, NICOLE · 2021 to 2023
$140kElucidating the Effects of Post-Translational Modifications on Tau Binding to F-actin and PSD95F31AG077836 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI MANCINELLI, CHIARA DIAMANTE · 2023 to 2025
$125kNCI NIH HHS P30 CA016087NHLBI NIH HHS F31 HL154651NIA NIH HHS F31 AG077836NIA NIH HHS RF1 AG066493NIH HHS S10 OD016320NIH HHS S10 OD028556NINDS NIH HHS R35 NS122209NINDS NIH HHS U01 NS134684
6 · The paper itselfAbstract
CHCHD10 is mutated in rare cases of FTD and ALS and aggregates in mouse models of disease. Here we show that the disordered N-terminal domain of CHCHD10 forms amyloid fibrils and report their cryoEM structure. Disease-associated mutations cannot be accommodated by the WT fibril structure, while sequence differences between CHCHD10 and CHCHD2 are tolerated, explaining the co-aggregation of the two proteins and linking CHCHD10 and CHCHD2 amyloid fibrils to neurodegeneration.
Identifiers
PMID39091724
PMCPMC11291021
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