Trial reportHead & neck2025
Preventing radiation-induced dysphagia and trismus in head and neck cancer-A randomized controlled trial.
Trial report in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04005521 (Preventive Randomized Study Regarding Jaw- and Swallowing Intervention for Patients Receiving Radiotherapy for Head and Neck Cancer), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventive Randomized Study Regarding Jaw- and Swallowing Intervention for Patients Receiving Radiotherapy for Head and Neck Cancer: the Effect of Preventive Intervention for Trismus, Swallowing Function and Quality of Life
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines for nutrition in adults with head and neck cancer: The American Society for Parenteral and Enteral Nutrition.JPEN. Journal of parenteral and enteral nutrition · 2026Guideline
- Jaw exercise in head and neck cancer patients for prevention of temporomandibular disorders: a randomized controlled trial.Journal of cancer survivorship : research and practice · 2026Trial
- Preventive exercise intervention for trismus in head and neck cancer - a randomized study : Preventive exercise intervention for trismus.Clinical oral investigations · 2026Trial
- A Telemedicine App for Nonrigid Facial Rehabilitation Training Enhanced by Efficient Fully Convolutional Neural Network With Residual Network (EffiFCNN-ResNet) to Improve Accessibility for Patients With Nasopharyngeal Carcinoma Cancer: Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- Preventing radiation-induced dysphagia and trismus in head and neck cancer-A randomized controlled trial.Head & neck · 2025Trial
- Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.BMC oral health · 2026Article
- Precision rehabilitation for swallowing dysfunction after radiotherapy in head and neck cancer: current evidence, key controversies, and future perspectives.Frontiers in oncology · 2026Review
- Evaluation of Treatment Modalities for Radiation Therapy-Induced Trismus, Considering the Timing and Adherence to Progress in Mouth Opening and Oral Health-Related Quality of Life: A Systematic Review.Patient preference and adherence · 2026Review
- Perceptions and Experiences of Physiotherapists Treating Trismus in Head and Neck Cancer Patients: Findings from a Spanish Web-Based Survey.Journal of clinical medicine · 2025Article
- The Rationale and Explanation for Rehabilitation Interventions in the Management of Treatment-Induced Trismus in People with Head and Neck Cancer: A Scoping Review of Randomized Controlled Trials.Medicina (Kaunas, Lithuania) · 2025Article
- "Women's experiences of head and neck cancer: an interpretative phenomenological analysis".BMC women's health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundRadiation-induced dysphagia and restricted mouth opening are common problems among patients with head and neck cancer. The aim of the present randomized controlled trial was to determine if an exercise protocol could prevent swallowing and mouth opening impairment.
methodsEighty-nine participants were randomly assigned to either an active group performing preventive swallowing and mouth opening exercises (n = 45) or to a control group (n = 44). Outcome measures were collected at baseline before radiotherapy and approximately 1-month post-treatment. Primary endpoints were changes in swallowing function according to the Penetration Aspiration Scale and mouth opening ability measured in millimeters. Intention-to-treat analysis was used.
resultsSwallowing function and mouth opening deteriorated in both groups, with no statistically significant positive effect of the protocol detected at follow-up. Among patients who completed >75% of exercises, there was a trend toward better outcomes.
conclusionsPreventive exercises did not improve short-term swallowing function and mouth opening after radiotherapy.
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