Evidence map›Paper›PMID 39090710›Full record

ArticleEuropean journal of oral sciences2024

The expression of immune checkpoint proteins PD-L1 and TIM3 in mouse and human head and neck squamous cell carcinoma.

Areeg Elmusrati, Cun-Yu Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of oral sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Areeg ElmusratiLaboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, California, USA.ORCID 0000-0003-3602-0532
Cun-Yu WangLaboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, California, USA.ORCID 0000-0002-3885-5149

Funding

Targeting Super-Enhancers Suppresses Cancer Stemness and Invasion of HNSCCR01DE029173 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, CUN-YU · 2020 to 2024
$2.0M
The Inhibition of HNSCC Growth and Metastasis by Targeting KDM4AR01DE030445 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, CUN-YU · 2021 to 2024
$1.6M
National Institute of Health / National Institute of Dental and Craniofacial Research NIH/NIDCR grants R01DE029173National Institute of Health / National Institute of Dental and Craniofacial Research NIH/NIDCR grants R01DE030445NIDCR NIH HHS R01 DE029173NIDCR NIH HHS R01 DE030445
6 · The paper itself

Abstract

The aim of this study was to examine the expression of programmed death-ligand 1 (PD-L1) and of T cell immunoglobulin and mucin domain-containing protein (TIM3) in oral epithelial dysplasia and head and neck squamous cell carcinoma (HNSCC). Mouse HNSCC was induced with 4-nitroquinoline-1 oxide (4NQO). Oral epithelial dysplastic lesions, carcinoma in situ and HNSCC lesions were stained with anti-PD-L1 and TIM3 antibodies. The expression of PD-L1 and TIM3 in tumor cells and immune cells was semiquantitatively measured and compared. In parallel, human dysplasia and HNSCC were stained with anti-PD-L1 and anti-TIM3. The expression pattern of PD-L1

Indexed as

B7-H1 AntigenHead and Neck NeoplasmsHepatitis A Virus Cellular Receptor 2Squamous Cell Carcinoma of Head and Neck4-Nitroquinoline-1-oxideAnimalsFemaleHumansMice4-Nitroquinoline-1-oxideB7-H1 AntigenCD274 protein, humanHAVCR2 protein, humanHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2head and neck squamous cell carcinomaimmune checkpoint proteinsimmunotherapy

Identifiers

PMID39090710
PMCPMC11436301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.