Evidence map›Paper›PMID 39090672›Full record

ArticleGenome biology2024

MAMS: matrix and analysis metadata standards to facilitate harmonization and reproducibility of single-cell data.

Irzam Sarfraz, Yichen Wang, Amulya Shastry, Wei Kheng Teh, Artem Sokolov, Brian R Herb, Heather H Creasy, Isaac Virshup, Ruben Dries, Kylee Degatano and 7 more

Abstract read
In one paragraph

Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Irzam SarfrazDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Yichen WangDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Amulya ShastryDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Wei Kheng TehEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, Cambridgeshire, UK.
Artem SokolovLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
Brian R HerbInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Heather H CreasyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Isaac VirshupDepartment of Computational Health, Helmholtz Munich, Oberschleißheim, Germany.
Ruben DriesDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Kylee DegatanoData Sciences Platform, Broad Institute, Cambridge, MA, USA.
Anup MahurkarInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Daniel J SchnellBiomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pedro MadrigalEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, Cambridgeshire, UK.
Jason HiltonDepartment of Genetics, Stanford University, Stanford, CA, USA.
Nils GehlenborgBiomedical Informatics, Harvard Medical School, Boston, MA, USA.
Timothy TickleData Sciences Platform, Broad Institute, Cambridge, MA, USA.
Joshua D CampbellDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA. camp@bu.edu.ORCID 0000-0003-0780-8662

Funding

The LungMAP Data Coordination Center for Next Gen Systems Biology of RespirationU24HL148865 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Bruce J Aronow, Nathan G. Salomonis · 2019 to 2026
$12.4M
The Lung PCA: A Multi-Dimensional Atlas of Pulmonary PremalignancyU2CCA233238 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SPIRA, AVRUM E · 2018 to 2021
$7.0M
NCI NIH HHS U2C CA233238NHLBI NIH HHS U24 HL148865Wellcome TrustWellcome Trust 108437/Z/15/Z
6 · The paper itself

Abstract

Many datasets are being produced by consortia that seek to characterize healthy and disease tissues at single-cell resolution. While biospecimen and experimental information is often captured, detailed metadata standards related to data matrices and analysis workflows are currently lacking. To address this, we develop the matrix and analysis metadata standards (MAMS) to serve as a resource for data centers, repositories, and tool developers. We define metadata fields for matrices and parameters commonly utilized in analytical workflows and developed the rmams package to extract MAMS from single-cell objects. Overall, MAMS promotes the harmonization, integration, and reproducibility of single-cell data across platforms.

Indexed as

MetadataSingle-Cell AnalysisHumansReproducibility of ResultsSoftware

Identifiers

PMID39090672
PMCPMC11292877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.