Evidence map›Paper›PMID 39090471›Full record

ArticleBulletin of experimental biology and medicine2024

Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer's Disease.

S A Zozulya, A A Akopyan, M V Tenditnik, M V Ovsyukova, T A Korolenko, T P Klyushnik, M A Tikhonova, A B Pupyshev

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trehalose's untapped mechanisms in alzheimer's: gut-brain-autophagy signalling beyond the usual targets.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

S A ZozulyaMental Health Research Center, Moscow, Russia. s.ermakova@mail.ru.
A A AkopyanResearch Institute of Neurosciences and Medicine, Novosibirsk, Russia.
M V TenditnikResearch Institute of Neurosciences and Medicine, Novosibirsk, Russia.
M V OvsyukovaResearch Institute of Neurosciences and Medicine, Novosibirsk, Russia.
T A KorolenkoResearch Institute of Neurosciences and Medicine, Novosibirsk, Russia.
T P KlyushnikMental Health Research Center, Moscow, Russia.
M A TikhonovaResearch Institute of Neurosciences and Medicine, Novosibirsk, Russia.
A B PupyshevResearch Institute of Neurosciences and Medicine, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In an experimental model of Alzheimer's disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression level of microglia activation marker Iba1 and affects the neutrophil degranulation activity. A potential anti-inflammatory effect of 4% trehalose solution associated with a decrease in the activity of leukocyte elastase in plasma was revealed.

Indexed as

Alzheimer DiseaseDisease Models, AnimalMicrogliaTrehaloseAnimalsAnti-Inflammatory AgentsCalcium-Binding ProteinsDisaccharidesInflammationLeukocyte ElastaseMaleMiceMicrofilament ProteinsNeutrophilsAif1 protein, mouseAnti-Inflammatory AgentsCalcium-Binding ProteinsDisaccharidesLeukocyte ElastaseMicrofilament ProteinsTrehaloseAlzheimer’s diseaseexperimental modelleukocyte elastasemicrogliatrehalose

Identifiers

PMID39090471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.