Evidence map›Paper›PMID 39090462›Full record

ArticleBulletin of experimental biology and medicine2024

Bacterial Opsonization Changes Adhesion Interactions between Endothelial Cells and Neutrophils in a Model of Experimental Septicemia.

S N Pleskova, S Z Bobyk, N A Bezrukov, E V Lazarenko

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

S N PleskovaResearch Laboratory of Scanning Probe Microscopy, Scientific Education Center Physics of Solid-State Nanostructures, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia. pleskova@mail.ru.
S Z BobykResearch Laboratory of Scanning Probe Microscopy, Scientific Education Center Physics of Solid-State Nanostructures, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
N A BezrukovResearch Laboratory of Scanning Probe Microscopy, Scientific Education Center Physics of Solid-State Nanostructures, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
E V LazarenkoResearch Laboratory of Scanning Probe Microscopy, Scientific Education Center Physics of Solid-State Nanostructures, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The influence of non-opsonized and opsonized S. aureus 2879M and E. coli 321 strains on the total strength of interaction between the endothelial cell and neutrophil during the docking process was studied using in vitro model of experimental septicemia. We observed a decrease in the force and work of adhesion between receptors of neutrophils and endothelial cells under the influence of non-opsonized strains and further decrease in the affinity of single interactions between cells under the influence of opsonized S. aureus, which was compensated by an increase in the number of contacts, as well as an increase in the force of adhesion under the influence of opsonized E. coli compared to non-opsonized bacteria, which remained below the control level, while adhesion work reaches the control level. Thus, opsonization of S. aureus aggravates the "immunological uncoupling" between neutrophils and endothelial cells, while opsonization of E. coli reduces the pathological effect compared to non-opsonized bacteria.

Indexed as

Endothelial CellsEscherichia coliNeutrophilsSepsisStaphylococcus aureusAnimalsBacterial AdhesionCell AdhesionHumansOpsonin ProteinsPhagocytosisOpsonin ProteinsEscherichia coliFS spectroscopyopsonizationsepticemiaStaphylococcus aureus

Identifiers

PMID39090462

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.