ArticleThe EMBO journal2024
An ancient role for CYP73 monooxygenases in phenylpropanoid biosynthesis and embryophyte development.
Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cloning and functional characterization of a cinnamate 4-hydroxylase (SmC4H) from the lycophyte Selaginella moellendorffii.Protoplasma · 2026Article
- Cytochrome P450 enzymes in the phenylpropanoid pathway: CYP73 and CYP98 candidate genes in Chara braunii, Anthoceros agrestis, Marchantia polymorpha and Physcomitrium patens.The Plant journal : for cell and molecular biology · 2026Article
- Plant-fungi interactions inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Biosynthetic Mechanisms of Plant Chlorogenic Acid from a Microbiological Perspective.Microorganisms · 2025Review
- CRISPR/Cas9 targeted genetic screening in Physcomitrella identifies novel cell division genes.Frontiers in plant science · 2025Article
- Cytochromes P450 evolution in the plant terrestrialization context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- The evolution of plant responses underlying specialized metabolism in host-pathogen interactions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A snapshot of the Physcomitrella N-terminome reveals N-terminal methylation of organellar proteins.Plant cell reports · 2024Article
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Authors and funding
10 authors.
Funding
Abstract
The phenylpropanoid pathway is one of the plant metabolic pathways most prominently linked to the transition to terrestrial life, but its evolution and early functions remain elusive. Here, we show that activity of the t-cinnamic acid 4-hydroxylase (C4H), the first plant-specific step in the pathway, emerged concomitantly with the CYP73 gene family in a common ancestor of embryophytes. Through structural studies, we identify conserved CYP73 residues, including a crucial arginine, that have supported C4H activity since the early stages of its evolution. We further demonstrate that impairing C4H function via CYP73 gene inactivation or inhibitor treatment in three bryophyte species-the moss Physcomitrium patens, the liverwort Marchantia polymorpha and the hornwort Anthoceros agrestis-consistently resulted in a shortage of phenylpropanoids and abnormal plant development. The latter could be rescued in the moss by exogenous supply of p-coumaric acid, the product of C4H. Our findings establish the emergence of the CYP73 gene family as a foundational event in the development of the plant phenylpropanoid pathway, and underscore the deep-rooted function of the C4H enzyme in embryophyte biology.
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