ArticleNature medicine2024
The burden of diabetes-associated multiple long-term conditions on years of life spent and lost.
Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative Effectiveness of Aerobic Exercise versus Resistance Training on Cardiometabolic Health in Patients with Diabesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of sports science & medicine · 2026Pooled it
- Integrating Mental Health into Diabetes Care: Closing the Treatment Gap for Better Outcomes-A Systematic Review.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Association of Oral Health Assessment Tool Findings With Periodontal Screening Outcomes in Adults With Diabetes.Clinical and experimental dental research · 2026Article
- Key Hepatokines Linking MASLD and Type 2 Diabetes: From Pathophysiological Mechanisms to Therapeutic Modulation.International journal of molecular sciences · 2026Review
- Heterogeneity of Treatment Effects Across Nine Glucose-Lowering Drug Classes in Type 2 Diabetes: Extension of the LEGEND-T2DM Network Study.Diabetes, obesity & metabolism · 2026Observational
- Trends in Potentially Avoidable Hospitalisations Among People With Diabetes in Ireland; 2015-2024.Diabetes, obesity & metabolism · 2026Article
- Latent profiles of diabetes distress and determinants in type 2 diabetes patients.BMC psychology · 2026Article
- Enzyme-Flavonoid Synergistic Hydrogel: Enables Glucose-Activated Cascade Acidification and Programmed Drug Release for Diabetic Wound Therapy.Gels (Basel, Switzerland) · 2026Article
- The impact of diabetes on clinical outcomes in acutely ill patients - a study on patients admitted to the emergency department.BMC cardiovascular disorders · 2026Article
- Banting memorial lecture 2025: Aligning clinical practice, policy and research.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Economic burden of type 2 diabetes management in France according to clinical characteristics.Diabetes, obesity & metabolism · 2026Article
- Fixed-Dose Combination Therapy as a Strategy to Improve Antidiabetic Medication Adherence in People with Type 2 Diabetes: A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- Prevalence and Association of Polypharmacy and Potentially Inappropriate Medications Among Older Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Pharmacy (Basel, Switzerland) · 2026Review
- Type 2 diabetes mellitus.Nature reviews. Disease primers · 2026Review
- Effect of exercise therapy and self-management support on multimorbidity: Secondary analysis of the MOBILIZE trial.Communications medicine · 2026Article
- Diabetes Fact Sheet 2025: Comparative Epidemiology and Clinical Features of Obese and Non-Obese Diabetes in Korea.Diabetes & metabolism journal · 2026Article
- AI-Assisted detection of corneal nerve structural abnormalities in early diabetic keratopathy: development and validation of a deep learning framework.Scientific reports · 2026Article
- Acute coronary syndrome as a turning point for guideline adherence and outcomes in heart failure with coronary artery disease and diabetes mellitus.European journal of clinical pharmacology · 2026Article
- Heterogeneity of Treatment Effects Across Nine Glucose-Lowering Drug Classes in Type 2 Diabetes: Extension of the LEGEND-T2DM Network Study.medRxiv : the preprint server for health sciences · 2026Article
- Health Galaxy: A Multi-organ Trajectory-Computing Framework in Type 2 Diabetes.Research (Washington, D.C.) · 2026Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Diabetes mellitus is a central driver of multiple long-term conditions (MLTCs), but population-based studies have not clearly characterized the burden across the life course. We estimated the age of onset, years of life spent and loss associated with diabetes-related MLTCs among 46 million English adults. We found that morbidity patterns extend beyond classic diabetes complications and accelerate the onset of severe MLTCs by 20 years earlier in life in women and 15 years earlier in men. By the age of 50 years, one-third of those with diabetes have at least three conditions, spend >20 years with them and die 11 years earlier than the general population. Each additional condition at the age of 50 years is associated with four fewer years of life. Hypertension, depression, cancer and coronary heart disease contribute heavily to MLTCs in older age and create the greatest community-level burden on years spent (813 to 3,908 years per 1,000 individuals) and lost (900 to 1,417 years per 1,000 individuals). However, in younger adulthood, depression, severe mental illness, learning disabilities, alcohol dependence and asthma have larger roles, and when they occur, all except alcohol dependence were associated with long periods of life spent (11-14 years) and all except asthma associated with many years of life lost (11-15 years). These findings provide a baseline for population monitoring and underscore the need to prioritize effective prevention and management approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.