ArticleCommunications medicine2024
Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences.
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Article in Communications medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of air pollution exposure and brain structure and function during development.Environmental research · 2025Pooled it
- Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer's disease by chemically distinct air pollutants.Redox biology · 2026Article
- From adolescence to Alzheimer's: a neurodevelopmental lifespan model of cognitive vulnerability.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- The Adolescent Brain Cognitive Development (ABCD) Study: Ten years of statistical and methodological contributions.Developmental cognitive neuroscience · 2026Article
- Ambient pollution components and sources are associated with hippocampal architecture and memory in pre-adolescents.BMC medicine · 2026Article
- White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026Article
- Highly replicable multisite patterns of adolescent white matter maturation.bioRxiv : the preprint server for biology · 2026Article
- Longitudinal associations between air pollution and adolescent gray matter development: Insights from the ABCD study.Environmental research · 2026Article
- Evolutionary sex bias in cognitive response to new environmental risk factor - PM2.5.Biology of sex differences · 2025Review
- Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems.PLoS biology · 2025Article
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.Molecular psychiatry · 2025Article
- The Impact of Early Life Exposure to Air Pollution on the Brain: A Diffusion MRI Study in 10-13-Year-Old Children With and Without ADHD Diagnosis.Human brain mapping · 2025Article
- Unraveling the impact of prenatal air pollution for neonatal brain maturation.Environment international · 2025Article
- Fine particulate matter air pollution and longitudinal gray matter development changes during early adolescence: variation by neighborhood disadvantage level.Environment international · 2025Article
- Sex-specific Effects of Outdoor Air Pollution on Subcortical Microstructure and Weight Gain: Findings from the ABCD StudybioRxiv : the preprint server for biology · 2025Article
- Article
- What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways.Brain, behavior, & immunity - health · 2025Review
- Structural and functional brain correlates of the neutrophil- and monocyte-to-lymphocyte ratio in neuropsychiatric disorders.Brain, behavior, & immunity - health · 2025Article
- Sleep moderates how prenatal and childhood pollutant exposure impacts white matter microstructural integrity in adolescence.Npj biological timing and sleep · 2025Article
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.medRxiv : the preprint server for health sciences · 2024Article
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Authors and funding
11 authors.
Devyn L CotterNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9955-7367
Hedyeh AhmadiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Carlos Cardenas-IniguezDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6736-3020
Katherine L BottenhornDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
W James GaudermanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rob McConnellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kiros BerhaneDepartment of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, USA.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6168-378X
Daniel A HackmanUSC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6968-5701
Jiu-Chiuan ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Megan M HertingDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. herting@usc.edu.ORCID http://orcid.org/0000-0002-0840-4582
Funding
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MTranslational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4MTranslational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7MABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9MFIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8MABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3MABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7MNIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES031074NIEHS NIH HHS R01 ES032295U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) 3P30ES000002-55S1U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) P30ES007048-23S1U.S. Environmental Protection Agency (US Environmental Protection Agency) RD 83587201
Abstract
backgroundAir pollution is ubiquitous, yet questions remain regarding its impact on the developing brain. Large changes occur in white matter microstructure across adolescence, with notable differences by sex.
methodsWe investigate sex-stratified effects of annual exposure to fine particulate matter (PM
resultsHere we show higher PM
conclusionsCriteria air pollutants influence patterns of white matter maturation between 9-13 years old, with some sex-specific differences in the magnitude and anatomical locations of affected tracts. This occurs at concentrations that are below current U.S. standards, suggesting exposure to low-level pollution during adolescence may have long-term consequences.
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