Evidence map›Paper›PMID 39090352›Full record

ArticleMolecular neurobiology2025

Efficiency of Cysticidal Therapy Impacted by the Host's Immune Response in Neurocysticercosis Patients.

Yashvi Mehta, Davinder Kaur, Upninder Kaur, Ritu Shree, Paramjeet Singh, Manish Modi, Vivek Lal, Rakesh Sehgal

Abstract read
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Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. In Vitro Evaluation of Esters of Quinoxaline-1,4-di-Pharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yashvi MehtaDepartment of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Davinder KaurDepartment of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Upninder KaurDepartment of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Ritu ShreeDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Paramjeet SinghDepartment of Radiodiagnosis, Neuroimaging & Interventional Neuroradiology Division, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Manish ModiDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Vivek LalDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Rakesh SehgalDepartment of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. sehgalpgi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurocysticercosis (NCC) is a neurological condition caused by the presence of cysts of Taenia solium in the brain, which manifests with a range of clinical symptoms. The severity of NCC and its prognosis following anti-helminth drug (AHD) treatment are closely linked to peripheral and local inflammation. The study aimed to analyse the efficiency of cysticidal therapy impacted by the host's immune response in NCC patients. A total of 104 patients were screened in this study, and blood samples were collected from 30 patients. The follow-up samples within 3 to 6 months of treatment were collected. Patients were categorised as Responder (R) and Non-Responder (NR). Cytokines IL-6, IL-10, IFN-γ and TNF-α were estimated using ELISA kits in PBMC cells. T0 is the time point before the AHD treatment begins, and T1 is between 3 to 6 months after the treatment starts. The responder patients showed significantly lower IL-10 and IL-6 levels in the supernatants at T0 as compared to T1, while in non-responder patients, IL-10 and IL-6 levels were higher at T0 as compared to T1. The IFN-γ and TNF-α levels were found to be higher in the supernatants at T0 as compared to T1 in both the responder and non-responder patients. These observations imply that these cytokines might have an impact on the efficacy of AHD treatment in NCC patients.

Indexed as

AnthelminticsImmunityNeurocysticercosisAdolescentAdultAnimalsCytokinesFemaleHumansLeukocytes, MononuclearMaleMiddle AgedTaenia soliumTreatment OutcomeYoung AdultAnthelminticsCytokinesAnti-Helminth DrugsImagingImmune ResponseNeurocysticercosisTreatment

Identifiers

PMID39090352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.