Evidence map›Paper›PMID 39090351›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2024

Blood absolute monocyte count trends in preterm infants with suspected necrotizing enterocolitis: an adjunct tool for diagnosis?

Meghan Moroze, Tricia Morphew, Lois W Sayrs, Azam Eghbal, W Nathan Holmes, Grant Shafer, Michel Mikhael

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Unplanned natural experiment: probiotics prevent necrotizing enterocolitis, a single center quality improvement report.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meghan MorozeDivision of Neonatology, CHOC Children's, Orange, CA, USA.
Tricia MorphewCHOC Children's Research Institute, Orange, CA, USA.
Lois W SayrsCHOC Children's Research Institute, Orange, CA, USA.ORCID 0000-0003-1633-0576
Azam EghbalDivision of Radiology, CHOC Children's, Orange, CA, USA.
W Nathan HolmesDivision of Radiology, CHOC Children's, Orange, CA, USA.
Grant ShaferDivision of Neonatology, CHOC Children's, Orange, CA, USA.ORCID 0000-0001-8726-0267
Michel MikhaelDivision of Neonatology, CHOC Children's, Orange, CA, USA. mmikhael@choc.org.ORCID 0000-0001-8307-6569

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe investigated the trends of blood absolute monocyte count (AMC) over 72 h after suspecting necrotizing enterocolitis (NEC). STUDY

designA single center, retrospective study, the AMC was plotted over 72 h after NEC evaluation. Receiver operating characteristic (ROC) curve analysis assessed change in AMC to identify absence of NEC and different NEC stages.

resultsIn 130 infants, the AMC decreased in patients with NEC stage 2 or 3. Stages 2 and 3 NEC experienced a drop in AMC compared to an increase in no NEC, possible NEC, or positive culture (p < 0.05). AMC increase 24% or less can differentiate NEC stage 2/3 from possible NEC with an area under the curve (AUC) of 0.78. While decrease of more than 32% can differentiate stage 2/3 vs. possible or no NEC with AUC of 0.71. DISCUSSION/

conclusionsA decrease in AMC can be an adjunct biomarker to confirm the diagnosis of NEC.

Indexed as

Enterocolitis, NecrotizingInfant, PrematureMonocytesROC CurveArea Under CurveBiomarkersFemaleGestational AgeHumansInfant, NewbornInfant, Premature, DiseasesLeukocyte CountMaleRetrospective StudiesBiomarkers

Identifiers

PMID39090351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.