Evidence map›Paper›PMID 39090323›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2024

Complete autonomic blockade reveals nitric oxide contribution to blood pressure regulation in obese Black women.

Sharla Rahman, Alfredo Gamboa, Mohammad Saleem, Surat Kulapatana, André Diedrich, Italo Biaggioni, Annet Kirabo, Cyndya A Shibao

Registry-linked trialAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01122407 (Obesity, Hypertension in African American Women, Neuro-metabolic Mechanism), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01122407 phase1completednot on this map

Obesity, Hypertension in African American Women, Neuro-metabolic Mechanism

TypeinterventionalSponsorVanderbilt University Medical CenterRan2010 to 2016Enrolled34ConditionsObesity, HypertensionArmsL-NMMA, Trimethaphan
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sharla RahmanDepartment of Medicine, Epidemiology, Vanderbilt University School of Medicine, Nashville, TN, 37212-8802, USA.
Alfredo GamboaDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37212-8802, USA.
Mohammad SaleemDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37212-8802, USA.
Surat KulapatanaDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37212-8802, USA.
André DiedrichDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37212-8802, USA.
Italo BiaggioniDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37212-8802, USA.
Annet KiraboDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, P415C Medical Research Building IV, 2215 Garland Avenue, Nashville, TN, 37232, USA. annet.kirabo@vumc.org.
Cyndya A ShibaoDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37212-8802, USA. cyndya.shibao@vumc.org.ORCID http://orcid.org/0000-0002-4518-6801

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Mechanism of Glucose-dependent insulinotropic polypeptide (GIP) on Splanchnic Venous Capacitance in Postural Tachycardia SyndromeR01HL159203 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Cyndya Adriana Shibao · 2022 to 2026
$4.1M
Enhancing parasympathetic activity to reduce vascular oxidative stress and endothelial dysfunctionR01HL157584 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET, SHIBAO, CYNDYA ADRIANA · 2021 to 2024
$3.0M
Sympathetic Mechanisms in the Cardiovascular and Metabolic Alterations of ObesityR01HL149386 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 2019 to 2023
$3.0M
Immune Mechanisms of Salt-Sensitive hypertensionR01HL144941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2021 to 2025
$3.0M
Autonomic Determinants of Postural Tachycardia SyndromeR01HL142583 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIEDRICH, ANDRE · 2019 to 2022
$1.7M
American Heart Association 23CDA1053072NCATS NIH HHS UL1 TR002243NHLBI NIH HHS R01 HL142583NHLBI NIH HHS R01HL142583NHLBI NIH HHS R01 HL144941NHLBI NIH HHS R01HL144941NHLBI NIH HHS R01 HL149386NHLBI NIH HHS R01HL149386NHLBI NIH HHS R01 HL157584NHLBI NIH HHS R01HL157584NHLBI NIH HHS R01 HL159203NHLBI NIH HHS R01HL159203Vanderbilt Institute for Clinical and Translational Research 5UL1TR002243-03
6 · The paper itself

Abstract

purposeHypertension is one of the major causes of cardiovascular morbidity and mortality in the USA and disproportionately affects Black women. Endothelial-derived nitric oxide (eNO) substantially regulates blood pressure in humans, and impaired NO-mediated vasodilation has been reported in the Black population. Previous studies using an NO synthase inhibitor, N

methodsL-NMMA at doses of 250 μg/kg per minute was infused in combination with trimethaphan at doses of 4 mg/min to eliminate baroreflex mechanisms. Heart rate (HR) was obtained with continuous electrocardiogram monitoring, and continuous blood pressure was measured with the volume clamp method. The increase in systolic blood pressure (SBP) during both infusions was used to estimate the contribution of NO to blood pressure.

resultsTen Black (age range 30-50 years, body mass index [BMI] 30-45 kg/m

conclusionAutonomic blood pressure regulation was similar between Black and White women. However, NO contribution to blood pressure was significantly greater in Black women compared to White women. REGISTRATION: ClinicalTrials.gov: NCT01122407.

Indexed as

BaroreflexBlood PressureNitric OxideObesityomega-N-MethylarginineAdultAutonomic Nervous SystemBlack or African AmericanFemaleGanglionic BlockersHeart RateHumansMiddle AgedTrimethaphanGanglionic BlockersNitric Oxideomega-N-MethylarginineTrimethaphanAutonomic blockadeBlood pressureL-NMMANitric oxideObesityTrimethaphan

Identifiers

PMID39090323
PMCPMC11362192

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.