Evidence map›Paper›PMID 39090229›Full record

SynthesisJournal of neurology2024

Cognitive deficits and course of recovery in transient global amnesia: a systematic review.

Ioannis Liampas, Panayiota Kyriakoulopoulou, Anna Akrioti, Polyxeni Stamati, Alexandra Germeni, Paraskevi Batzikosta, Eirini Tsiamaki, Dimitra Veltsista, Zinovia Kefalopoulou, Vasileios Siokas and 2 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ioannis LiampasDepartment of Neurology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Mezourlo Hill, 41100, Larissa, Greece. iliampas@uth.gr.ORCID http://orcid.org/0000-0002-2958-5220
Panayiota Kyriakoulopoulou *Department of Neurology, University Hospital of Patras, School of Medicine, University of Patras, 26504, Patras, Rio, Greece.
Anna Akrioti *Department of Neurology, University Hospital of Patras, School of Medicine, University of Patras, 26504, Patras, Rio, Greece.
Polyxeni StamatiDepartment of Neurology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Mezourlo Hill, 41100, Larissa, Greece.
Alexandra GermeniDepartment of Neurology, University Hospital of Patras, School of Medicine, University of Patras, 26504, Patras, Rio, Greece.
Paraskevi BatzikostaDepartment of Neurology, University Hospital of Patras, School of Medicine, University of Patras, 26504, Patras, Rio, Greece.
Eirini TsiamakiDepartment of Neurology, University Hospital of Patras, School of Medicine, University of Patras, 26504, Patras, Rio, Greece.
Dimitra VeltsistaDepartment of Neurology, University Hospital of Patras, School of Medicine, University of Patras, 26504, Patras, Rio, Greece.
Zinovia KefalopoulouDepartment of Neurology, University Hospital of Patras, School of Medicine, University of Patras, 26504, Patras, Rio, Greece.
Vasileios SiokasDepartment of Neurology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Mezourlo Hill, 41100, Larissa, Greece.
Elisabeth ChroniDepartment of Neurology, University Hospital of Patras, School of Medicine, University of Patras, 26504, Patras, Rio, Greece.
Efthimios DardiotisDepartment of Neurology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Mezourlo Hill, 41100, Larissa, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePublished evidence suggests that cognitive impairment during a TGA (transient global amnesia) spell may not be confined to episodic memory. We undertook a systematic review to determine the pattern of cognitive deficits during a TGA episode. As a secondary objective, we aimed to delineate the course of cognitive recovery.

methodsMEDLINE, EMBASE, CENTRAL, and Google scholar were systematically searched up to October 2023. Observational controlled studies including 10 or more TGA patients (Hodges and Warlow criteria) were retrieved. Data from case-control, cross-sectional, and cohort studies were reviewed and qualitatively synthesized.

resultsLiterature search yielded 1302 articles. After the screening of titles and abstracts, 115 full texts were retrieved and 17 of them were included in the present systematic review. During the acute phase, spatiotemporal disorientation, dense anterograde and variable retrograde amnesia, semantic memory retrieval difficulties, and working memory deficits comprised the neuropsychological profile of patients with TGA. Visuospatial abilities, attention and psychomotor speed, semantic memory, confrontation naming, and other measures of executive function (apart from semantic fluency and working memory) were consistently found normal. In the course of recovery, after the resolution of repetitive questioning, the restoration of spatiotemporal orientation follows, working memory and semantic memory retrieval ensue, while episodic memory impairment persists for longer. Meticulous evaluations may reveal subtle residual memory (especially recognition) deficits even after 24 h.

conclusionsΜemory impairment, spatiotemporal disorientation, and working memory deficits constitute the pattern of cognitive impairment during a TGA spell. Residual memory deficits may persist even after 24 h.

Indexed as

Amnesia, Transient GlobalCognitive DysfunctionHumansRecovery of FunctionAttentionExecutive functionLanguageMemoryProcessing speedVisuospatial skills

Identifiers

PMID39090229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.