Evidence map›Paper›PMID 39089951›Full record

ArticleJournal of pediatric urology2025

Histologic analysis of gonadal tissue in patients with Turner syndrome and Y chromosome material.

Julia Bhuiyan, Raghuveer Kavarthapu, Mary Soliman, G Thomas Brown, Jacqueline C Yano, Tazim Dowlut-McElroy, Veronica Gomez-Lobo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia BhuiyanEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. Electronic address: jbhuiyan@college.harvard.edu.
Raghuveer KavarthapuEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Mary SolimanEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
G Thomas BrownNational Cancer Institute, Bethesda, MD, USA.
Jacqueline C YanoEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Tazim Dowlut-McElroyPediatric and Adolescent Gynecology, Department of Surgery, Children's Mercy Hospital, Kansas City, MO, USA.
Veronica Gomez-LoboEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

Funding

Pediatric and Adolescent Gynecology Training ProgramZIEHD008985 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI GOMEZ-LOBO, VERONICA · 2022 to 2025
$9.3M
Ovarian tissue for fertility preservation-which will involve 2 IRB approved protocols: 000106 and 000715ZIAHD009005 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI GOMEZ-LOBO, VERONICA · 2022 to 2025
$2.4M
Rare conditions in PAG-which will involve 4 other protocols ZIAHD009006 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI GOMEZ-LOBO, VERONICA · 2022 to 2025
$2.4M
Intramural NIH HHS ZIA HD009005
6 · The paper itself

Abstract

This study investigates gonadal histology in individuals with Turner syndrome assigned female at birth and Y-chromosome material (TS+Y) who underwent prophylactic gonadectomy. Despite case reports suggesting spontaneous menarche and pregnancies in TS+Y, this research reveals the absence of germ cells, indicating low fertility likelihood. Germ cell neoplasia in-situ was present in some patients, emphasizing a non-negligible risk of cancer precursor. As no malignancies were found even in older individuals, the study challenges the immediate need for prophylactic gonadectomy upon TS+Y diagnosis. Limited fertility benefits are suggested, emphasizing the need for further research on optimal timing and criteria for the procedure.

Indexed as

Chromosomes, Human, YOvaryTurner SyndromeAdolescentCastrationChildChild, PreschoolFemaleGonadoblastomaHumansHysterosalpingographyInfantInfant, NewbornNeoplasms, Gonadal TissueGonadal dysgenesisGonadal tumorsGonadectomyTurner syndrome

Identifiers

PMID39089951
PMCPMC11757796

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.