Evidence map›Paper›PMID 39089880›Full record

ArticleLife science alliance2024

Transcriptional and methylation outcomes of didehydro-cortistatin A use in HIV-1-infected CD4

Luisa P Mori, Michael J Corley, Andrew T McAuley, Alina Pang, Thomas Venables, Lishomwa C Ndhlovu, Matthew E Pipkin, Susana T Valente

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luisa P MoriThe Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL, USA.
Michael J CorleyDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.
Andrew T McAuleyDepartment of Immunology and Microbiology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Alina PangDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.
Thomas VenablesDepartment of Immunology and Microbiology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Lishomwa C NdhlovuDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.
Matthew E PipkinThe Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL, USA.
Susana T ValenteThe Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL, USA svalente@ufl.edu.ORCID 0000-0002-7854-7554

Funding

HOPE - HIV Obstruction by Programmed EpigeneticsUM1AI164559 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Lishomwa C Ndhlovu, Melanie Maria Ott · 2021 to 2026
$32.2M
Mode of action of a new Tat HIV-1 inhibitorR01AI097012 · NIAID · UNIVERSITY OF FLORIDA · PI VALENTE, SUSANA T · 2012 to 2022
$7.5M
Evaluation of didehydro-Cortistatin A as a block-and-lock agent for a functional HIV cure in a macaque modelR01AI167732 · NIAID · UNIVERSITY OF FLORIDA · PI David T Evans, Susana T Valente · 2021 to 2026
$4.3M
Development of Brain Organoids to Study the Impact of HIV-1, Drugs of Abuseand Aging on Cognitive ImpairmentR01DA052027 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI NDHLOVU, LISHOMWA C, NIXON, DOUGLAS F · 2020 to 2024
$3.7M
Exploration of novel block-and-lock agents alone and in combination for HIV remission in humanized miceR01AI177327 · NIAID · UNIVERSITY OF FLORIDA · PI J. Victor Garcia-Martinez, Susana T Valente · 2023 to 2026
$3.5M
Identification and characterization of chromatin regulators of HIV-1 latencyR61AI140439 · NIAID · SCRIPPS FLORIDA · PI VALENTE, SUSANA T · 2018 to 2020
$2.8M
Host factors regulating HIV latency and reactivationR37AI165137 · NIAID · UNIVERSITY OF FLORIDA · PI Susana T Valente · 2022 to 2026
$2.0M
Identification and characterization of chromatin regulators of HIV-1 latencyR33AI140439 · NIAID · UNIVERSITY OF FLORIDA · PI VALENTE, SUSANA T · 2021 to 2022
$1.8M
Molecular Studies of Hepatitis C Virus.Z01AI000970 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI EMERSON, SUZANNE U · 2006 to 2008
$749k
Validation and characterization of Tat inhibitors identified through HTSR21AI158296 · NIAID · UNIVERSITY OF FLORIDA · PI VALENTE, SUSANA T · 2021 to 2022
$509k
Host factors regulating HIV latency and reactivationR56AI165137 · NIAID · SCRIPPS FLORIDA · PI VALENTE, SUSANA T · 2021 to 2021
$463k
Host factors regulating HIV latency and reactivationR01AI165137 · NIAID · SCRIPPS FLORIDA · PI VALENTE, SUSANA T · 2022 to 2022
$0k
Intramural NIH HHS Z01 AI000970NIAID NIH HHS R01 AI097012NIAID NIH HHS R01 AI165137NIAID NIH HHS R01 AI167732NIAID NIH HHS R01 AI177327NIAID NIH HHS R21 AI158296NIAID NIH HHS R33 AI140439NIAID NIH HHS R37 AI165137NIAID NIH HHS R56 AI165137NIAID NIH HHS R61 AI140439NIAID NIH HHS UM1 AI164559NIDA NIH HHS R01 DA052027
6 · The paper itself

Abstract

Ongoing viral transcription from the reservoir of HIV-1 infected long-lived memory CD4

Indexed as

CD4-Positive T-LymphocytesDNA MethylationHeterocyclic Compounds, 4 or More RingsHIV-1HIV InfectionsEpigenesis, GeneticHumansIsoquinolinesTh1 CellsTranscription, Geneticdidehydro-cortistatin AHeterocyclic Compounds, 4 or More RingsIsoquinolines

Identifiers

PMID39089880
PMCPMC11294679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.