Evidence map›Paper›PMID 39089703›Full record

ArticlePsychiatry investigation2024

Efficacy and Side Effects of Mixed-Strategy Electroconvulsive Therapy: A Proof-of-Concept Randomized Clinical Trial on Late Life Depression.

Si-Wen Lv, Yan Sun, Yang Chen, Chen Wang, Xin-Hui Xie, Xiao-Min Hu, Hong Hong, Lou-Feng Zhang, Nan-Nan Zhu, Peng-Yv Xie and 3 more

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Article in Psychiatry investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Si-Wen LvAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Yan SunDepartment of Geriatric Endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yang ChenAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Chen WangAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Xin-Hui XieDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
Xiao-Min HuAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Hong HongAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Lou-Feng ZhangAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Nan-Nan ZhuAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Peng-Yv XieAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Li ZhangAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Ling ChenAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.
Xiao-Ming KongAffiliated Psychological Hospital of Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei, China.

Funding

Applied Research Foundation of Hefei Hwk2022zd06Scientific Research Foundation of Anhui Medical University 2021xkj144The Doctoral Foundation of the First Affiliated Hospital of Anhui Medical University 2017-1280University Natural Science Research Project of Anhui Province KJ2021A0354
6 · The paper itself

Abstract

objectivePatients with late life depression sometimes refuse to receive electroconvulsive therapy (ECT) owing to its adverse reactions. To alleviate patient's resistance, a novel ECT stimulation strategy named mixed-strategy ECT (msECT) was designed in which patients are administered conventional ECT during the first three sessions, followed by low energy stimulation during the subsequent sessions. However, whether low energy electrical stimulation in the subsequent stage of therapy affect its efficacy and reduce adverse reactions in patients with late life depression remains unknown. To explore differences between msECT and regular ECT(RECT) with respect to clinical efficacy and side effects.

methodsThis randomized, controlled trial was conducted from 2019 to 2021 on 60 patients with late life depression who were randomly assigned to two groups: RECT or msECT. A generalized estimating equation (GEE) was used to compare the two stimulation strategies regarding their efficacy and side effects on cognition. Chi-squared test was used to compare side effects in the two strategies.

resultsIn the intent-to-treat group, the GEE model suggested no differences between-group difference in Hamilton Depression Rating Scale-17 score over time (Wald χ2=7.275, p=0.064), whereas the comparison of side effects in the two strategies favored msECT (Wald χ2=8.463, p=0.015) as fewer patients had adverse events during the second phase of treatment with msECT (χ2 =13.467, p=0.004).

conclusionmsECT presents its similar efficacy to RECT. msECT may have milder side effects on cognition.

Indexed as

Electroconvulsive therapyLate life depressionMixed-strategy electrotherapyRandomized controlled trial

Identifiers

PMID39089703
PMCPMC11298271

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