Evidence map›Paper›PMID 39089631›Full record

ArticleJournal of hepatology2025

Transposon-based oncogene integration in Abcb4(Mdr2)

Pinzhu Huang, Guangyan Wei, Jesse D Kirkpatrick, Yi Lin, Li Tan, Heansika Matta, Imad Nasser, Mingzhe Huang, Li Chen, Mathieu Petitjean and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Pinzhu HuangDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Colon and Rectum Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Guangyan WeiDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jesse D KirkpatrickKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yi LinDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Gastroenterology and Hepatology, Fujian Provincial Hospital, Fuzhou, China.
Li TanDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Heansika MattaDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Imad NasserDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Mingzhe HuangDepartment of Colon and Rectum Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Li ChenPharmaNest, Inc, NJ, USA.
Mathieu PetitjeanPharmaNest, Inc, NJ, USA.
Disha Skelton-BadlaniDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Wen GaoDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Kahini VaidDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Shuangshuang ZhaoDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Alicia LugovskoyDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Maram AlenziDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Xin ChenUniversity of Hawaii Cancer Center, Honolulu, HI USA.
Gregory J GoresDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Yury V PopovDivision of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: ypopov@bidmc.harvard.edu.

Funding

Role of Cancer-Associated Fibroblasts in CholangiocarcinomaR01CA228483 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHEN, XIN, SCHWABE, ROBERT F. · 2018 to 2022
$3.1M
Mitochondrial DAMPs-driven Mechanisms of Liver Fibrosis in NASHR01DK139288 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Yury Popov · 2024 to 2026
$2.0M
NCI NIH HHS R01 CA228483NIDDK NIH HHS R01 DK139288
6 · The paper itself

Abstract

BACKGROUND &

aimsCholangiocarcinoma (CCA) is a dreaded complication of primary sclerosing cholangitis (PSC) that is difficult to diagnose and associated with high mortality. A lack of animal models of CCA recapitulating the hepatic microenvironment of sclerosing cholangitis has hindered the development of novel treatments. Herein, we sought to develop a mouse model of PSC-associated CCA.

methodsTen-week-old Mdr2

resultsWhile SB AKT/YAP1 plasmids administered via retrograde biliary injection caused tumors in Mdr2

conclusionWe established a new high-fidelity cholangiocarcinoma model in mice, termed SB CCA.Mdr2 IMPACT AND IMPLICATIONS: Animal models for primary sclerosing cholangitis (PSC)-related cholangiocarcinoma (PSC-CCA) are lacking. Thus, we have developed and characterized a new mouse model of PSC-CCA, termed SB CCA.Mdr2

Indexed as

ATP-Binding Cassette Sub-Family B Member 4Bile Duct NeoplasmsCholangiocarcinomaCholangitis, SclerosingDisease Models, AnimalAnimalsATP Binding Cassette Transporter, Subfamily BDNA Transposable ElementsHumansMiceMice, KnockoutOncogenesProto-Oncogene Proteins c-aktYAP-Signaling ProteinsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BDNA Transposable ElementsProto-Oncogene Proteins c-aktYap1 protein, mouseYAP-Signaling ProteinsABCB4cholangiocarcinomamouse modelprimary sclerosing cholangitisTGFβ

Identifiers

PMID39089631
PMCPMC11655257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.