Evidence map›Paper›PMID 39088894›Full record

ArticleJournal of the neurological sciences2024

Age-associated gadolinium leakage into ocular structures in patients with acute traumatic brain injury.

Emily Baniewicz, Nicole Peterkin, Marie Luby, Kyle C Kern, Rebecca F Gottesman, Lawrence L Latour, L Christine Turtzo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the neurological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily BaniewiczAcute Cerebrovascular Diagnostics Unit, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room B1D733, Bethesda, MD 20892, USA.
Nicole PeterkinAcute Cerebrovascular Diagnostics Unit, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room B1D733, Bethesda, MD 20892, USA.
Marie LubyAcute Cerebrovascular Diagnostics Unit, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room B1D733, Bethesda, MD 20892, USA.
Kyle C KernStroke, Cognition, and Neuroepidemiology Section, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room 4D37A, Bethesda, MD 20892, USA; Department of Neurology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Rebecca F GottesmanStroke, Cognition, and Neuroepidemiology Section, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room 4D37A, Bethesda, MD 20892, USA.
Lawrence L LatourAcute Cerebrovascular Diagnostics Unit, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room B1D733, Bethesda, MD 20892, USA.
L Christine TurtzoAcute Cerebrovascular Diagnostics Unit, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room B1D733, Bethesda, MD 20892, USA. Electronic address: l.turtzo@nih.gov.

Funding

Eval, Pathogenesis, Outcome of Subjects with or Suspected Traumatic Brain InjuryZIANS003120 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LATOUR, LAWRENCE · 2010 to 2025
$16.5M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
Intramural NIH HHS Z99 NS999999Intramural NIH HHS ZIA NS003120
6 · The paper itself

Abstract

backgroundGadolinium Leakage into Ocular Structures (GLOS) is common following acute cerebrovascular events. The objective of this study was to investigate the occurrence of GLOS in an acute traumatic brain injury (TBI) cohort without acute cerebrovascular injury and to explore associated factors.

methodsEnrolled acute TBI patients had a baseline MRI ≤48 h of injury (TP1) and follow-up MRI ≤72 h after baseline (TP2). Vitreous chamber enhancement and signal intensity ratios (SIRs) were calculated using pre- and post-contrast Fluid Attenuated Inversion Recovery (FLAIR). White matter hyperintensities (WMHs) were assessed using the Fazekas scale.

resultsOf the 128 TBI patients included, median age was 47 years, 70% male, and 66% presented with Glasgow Coma Scale of 15. No GLOS was detected at TP1 but was present in 23% of patients at TP2. GLOS+ patients were older (68 years [56-76] vs 39 years [27-53], p < 0.001), more likely to report falls as injury mechanism (62% vs 36%, p = 0.006), report history of hypertension (41% vs 19%, p = 0.025), and had a higher burden of WMHs (59% vs 14% with a total Fazekas ≥2, p < 0.001). Quantitative SIRs confirmed qualitative assessments: GLOS+ patients had higher SIRs at TP2 (0.43 vs 0.22, p < 0.001). Age (OR 3.28, 95%CI [1.88-5.71], p < 0.001) and prior TBI history (OR 4.99, 95%CI [1.46-17.06], p = 0.010) were independent predictors of GLOS. When age was removed, total Fazekas score (OR 2.53, 95%CI [1.60-4.00], p < 0.001) was an independent predictor of GLOS.

conclusionsGLOS is primarily associated with age and may serve as another imaging marker of chronic vascular disease.

Indexed as

Brain Injuries, TraumaticGadoliniumMagnetic Resonance ImagingAdultAgedAge FactorsCohort StudiesContrast MediaFemaleHumansMaleMiddle AgedContrast MediaGadoliniumBlood-ocular barrier disruptionCerebral small vessel diseaseGadolinium leakage into ocular structuresMRITraumatic brain injury

Identifiers

PMID39088894
PMCPMC11348874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.