Evidence map›Paper›PMID 39088766›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024

Randomized Controlled Trial of a Nurse-Led Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer.

Joseph A Greer, Kathryn E Post, Reena Chabria, Seetha Aribindi, Natalie Brennan, Ijeoma Julie Eche-Ugwu, Barbara Halpenny, Erica Fox, Stephen Lo, Lauren P Waldman and 5 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06791057 (Multi-site Trial of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06791057 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Multi-site Trial of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer

TypeinterventionalSponsorMassachusetts General HospitalRan2026 to 2030Enrolled420ConditionsAdvanced Lung Cancer, DyspneaArmsDyspnea Intervention, Enhanced Usual Care
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Palliative care interventions for thoracic cancer: a systematic review and meta-analysis identifying the core elements.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  3. Nonpharmacological dyspnoea-relief strategies in lung cancer: a systematic review and network meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Survivorship Challenges and Supportive Care in Lung Cancer.Seminars in respiratory and critical care medicine · 2025
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Joseph A GreerMassachusetts General Hospital, Boston, MA.ORCID 0000-0002-0979-4076
Kathryn E PostMassachusetts General Hospital, Boston, MA.ORCID 0000-0002-1777-5158
Reena ChabriaMassachusetts General Hospital, Boston, MA.ORCID 0009-0005-5938-9254
Seetha AribindiMassachusetts General Hospital, Boston, MA.ORCID 0000-0001-5344-4455
Natalie BrennanMassachusetts General Hospital, Boston, MA.
Ijeoma Julie Eche-UgwuHarvard Medical School, Boston, MA.ORCID 0000-0002-9024-6228
Barbara HalpennyDana-Farber Cancer Institute, Boston, MA.ORCID 0000-0001-6273-8674
Erica FoxDana-Farber Cancer Institute, Boston, MA.
Stephen LoMassachusetts General Hospital, Boston, MA.ORCID 0000-0002-7094-8898
Lauren P WaldmanBrigham and Women's Hospital, Boston, MA.
Kedie PintroMassachusetts General Hospital, Boston, MA.
Dustin J RabideauMassachusetts General Hospital, Boston, MA.ORCID 0000-0002-3829-7079
William F PirlHarvard Medical School, Boston, MA.ORCID 0000-0001-5226-9886
Mary E CooleyHarvard Medical School, Boston, MA.ORCID 0000-0001-5353-9542
Jennifer S TemelMassachusetts General Hospital, Boston, MA.ORCID 0000-0002-7268-5921

Funding

Brief Behavioral Intervention for Dyspnea in Patients with Advanced Lung CancerR01NR016694 · NINR · MASSACHUSETTS GENERAL HOSPITAL · PI GREER, JOSEPH ANDREW, TEMEL, JENNIFER SUE · 2017 to 2021
$2.5M
NINR NIH HHS R01 NR016694
6 · The paper itself

Abstract

purposeIn patients with lung cancer, dyspnea is one of the most prevalent and disabling symptoms, for which effective treatments are lacking. We examined the efficacy of a nurse-led brief behavioral intervention to improve dyspnea in patients with advanced lung cancer.

methodsPatients with advanced lung cancer reporting at least moderate breathlessness (n = 247) were enrolled in a randomized trial of a nurse-led two-session intervention (focused on breathing techniques, postural positions, and fan therapy) versus usual care. At baseline and weeks 8 (primary end point), 16, and 24, participants completed measures of dyspnea (Modified Medical Research Council Dyspnea Scale [mMRCDS]; Cancer Dyspnoea Scale [CDS]), quality of life (Functional Assessment of Cancer Therapy-Lung [FACT-L]), psychological symptoms (Hospital Anxiety and Depression Scale), and activity level (Godin-Shephard Leisure Time Physical Activity Questionnaire). To examine intervention effects, we conducted analysis of covariance and longitudinal mixed effects models.

resultsThe sample (Age

conclusionFor patients with advanced lung cancer, a scalable behavioral intervention alleviated the intractable symptom of dyspnea. Further research is needed on ways to enhance intervention effects over the long-term and across additional outcomes.

Indexed as

Behavior TherapyDyspneaLung NeoplasmsNursesAgedFemaleHumansMaleMiddle AgedNeoplasm StagingQuality of Life

Identifiers

PMID39088766
PMCPMC11483213

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.