ReviewMedicina oral, patologia oral y cirugia bucal2024
Head and neck myofibroma: A case series of 16 cases and literature review.
Review in Medicina oral, patologia oral y cirugia bucal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Solitary Myofibroma of the Nasal Septum: A Rare Clinical Entity.Journal of rhinology : official journal of the Korean Rhinologic Society · 2026Article
- Myofibroma of the nasal vestibule: a case report and review of the literature.Journal of surgical case reports · 2026Article
- A Rare Case of Myofibroma of the Mandible Complicated by Traumatic Neuroma Arising After a Conservative Surgical Approach.Journal of clinical and experimental dentistry · 2025Article
- Myopericytoma in the oral cavity: a rare case report and literature review.International journal of clinical and experimental pathology · 2025Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to explore the clinical, histopathologic, and immunohistochemical characteristics of myofibromas (MFs) affecting the head and neck region. MATERIAL AND
methodsFormalin-fixed paraffin-embedded tissue blocks of patients diagnosed with MFs in the head and neck were retrieved from the archives of three oral and maxillofacial pathology laboratories. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed, and follow-up status were retrieved from the patient's medical records or pathology reports.
resultsSixteen cases were included in the study. Females were slightly more affected than males. The first and second decades of life were more prevalent. The most common locations were the alveolar ridge and cheek. Although rare, some of the patients were presented with intraosseous lesions. Microscopically, tumors consisted of plump, spindle-shaped myofibroblasts arranged in whorls or fascicles with varying degrees of differentiation. Immunohistochemically, diffuse positivity for vimentin and α-SMA was observed, while Ki-67 mostly showed low immunoreactivity (<5%). Treatment primarily involved complete excision.
conclusionsMFs in the head and neck region are rare and predominantly affect female patients during the second decade of life. Despite their rarity, central MFs should be considered in the differential diagnosis of intraosseous lesions in infants.
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