Evidence map›Paper›PMID 39088318›Full record

ArticleCell reports2024

Calcineurin is an adaptor required for assembly of the TCR signaling complex.

Shizuka Otsuka, Debjani Dutta, Chuan-Jin Wu, Muhammad S Alam, Jonathan D Ashwell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shizuka OtsukaLaboratory of Immune Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.
Debjani DuttaLaboratory of Immune Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.
Chuan-Jin WuLaboratory of Immune Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.
Muhammad S AlamLaboratory of Immune Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.
Jonathan D AshwellLaboratory of Immune Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jda@pop.nci.nih.gov.

Funding

T cell receptor proximal signalingZIABC011715 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ASHWELL, JONATHAN · 2016 to 2024
$4.7M
Intramural NIH HHS ZIA BC011715
6 · The paper itself

Abstract

The serine/threonine phosphatase calcineurin is a component of the T cell receptor (TCR) signalosome, where it promotes T cell activation by dephosphorylating Lck

Indexed as

CalcineurinReceptors, Antigen, T-CellSignal TransductionAdaptor Proteins, Signal TransducingHumansJurkat CellsLymphocyte Specific Protein Tyrosine Kinase p56(lck)PhosphorylationT-LymphocytesZAP-70 Protein-Tyrosine KinaseAdaptor Proteins, Signal TransducingCalcineurinLymphocyte Specific Protein Tyrosine Kinase p56(lck)Receptors, Antigen, T-CellZAP-70 Protein-Tyrosine Kinaseactin reorganizationCP: Immunologyproximal T cell signalingTCR microclustersTCR signalosome

Identifiers

PMID39088318
PMCPMC11407306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.