Evidence map›Paper›PMID 39088183›Full record

ArticleJA clinical reports2024

A case of opioid-induced rigidity requiring naloxone administration at the time of anesthesia emergence.

Ryohei Fukasawa, Ayumi Oishi, Chiaki Nemoto, Satoki Inoue

Abstract read
In one paragraph

Article in JA clinical reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryohei FukasawaDepartment of Anesthesiology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Ayumi OishiDepartment of Anesthesiology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Chiaki NemotoDepartment of Anesthesiology, Ohara General Hospital, 6-1 Ohomachi, Fukushima, 960-8611, Japan. nemo@fmu.ac.jp.
Satoki InoueDepartment of Anesthesiology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOpioid-induced rigidity is typically observed during rapid administration of fentanyl. Herein, we present a case in which rigidity occurred after reversal of rocuronium during emergence from anesthesia. CASE PRESENTATION: A 73-year-old man underwent video-assisted partial lung resection. General anesthesia was induced with propofol, remimazolam, remifentanil, and rocuronium. Fentanyl was administered early during anesthesia. The surgery was completed without complications, and sugammadex sodium was administered for rocuronium reversal. The patient became agitated, but spontaneous breathing was maintained; therefore, the intratracheal tube was removed after the administration of flumazenil. The patient developed stiffness in the neck and jaw muscles along with remarkable skeletal muscle contractions. Dramatic improvement was observed immediately after administration of naloxone.

conclusionsEven as the simulated effect site concentration of fentanyl decreases during anesthesia emergence, opioid-induced rigidity may still occur. Rapid reversal of remimazolam by flumazenil might have contributed to the rigidity in this case.

Indexed as

Anesthetic emergence agitationFentanylNaloxoneOpioid-induced rigidity

Identifiers

PMID39088183
PMCPMC11294279

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.