Evidence map›Paper›PMID 39087899›Full record

ArticleCancer medicine2024

Rectal adenocarcinoma: Ex vivo 9.4T MRI-correlation with histopathologic treatment response to neoadjuvant chemoradiotherapy.

Zhihui Li, Yuan Yuan, Minglu Liu, Tingting Bo, Xiaolu Ma, Hanqi Wang, Chen Chen, Xiaohui Shi, Hao Wang, Chenguang Bai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhihui LiDepartment of Radiology, Ruijin Hospital Luwan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yuan YuanDepartment of Radiology, Changhai Hospital, The Navy Medical University, Shanghai, China.
Minglu LiuDepartment of Radiology, Changhai Hospital, The Navy Medical University, Shanghai, China.
Tingting BoDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaolu MaDepartment of Radiology, Changhai Hospital, The Navy Medical University, Shanghai, China.
Hanqi WangDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen ChenUnited Imaging Healthcare, Shanghai, China.
Xiaohui ShiDepartment of Colorectal Surgery, Changhai Hospital, The Navy Medical University, Shanghai, China.
Hao WangDepartment of Colorectal Surgery, Changhai Hospital, The Navy Medical University, Shanghai, China.
Chenguang BaiDepartment of Pathology, Changhai Hospital, The Navy Medical University, Shanghai, China.
Xiang NiDepartment of Pathology, Changhai Hospital, The Navy Medical University, Shanghai, China.
Chengwei ShaoDepartment of Radiology, Changhai Hospital, The Navy Medical University, Shanghai, China.
Yong LuDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jianping LuDepartment of Radiology, Changhai Hospital, The Navy Medical University, Shanghai, China.ORCID 0000-0002-0380-7470
Fu ShenDepartment of Radiology, Changhai Hospital, The Navy Medical University, Shanghai, China.ORCID 0000-0001-8596-9563

Funding

Changhai Hospital of Shanghai GH145-09Foundation of Shanghai Municipal Health Commission 202240204National Natural Science Foundation of China 82171891Science and Technology Commission of Shanghai Municipality 21ZR1439800Shanghai Science International Cooperation Project 22490713400young medical talents funding project of Shanghai
6 · The paper itself

Abstract

objectivesTo determine the imaging details and diagnostic information of the treatment response to neoadjuvant chemoradiotherapy (nCRT) of rectal adenocarcinoma at 9.4T magnetic resonance imaging (MRI) by ex vivo.

methodsFifteen cases with locally advanced rectal cancer (LARC) followed by radical surgery after nCRT between September 2022 and February 2023 were recruited. Resected specimens were fixed in a perfluoropolyether-filled test tube and scanned with a 3.0T and 9.4T MRI system ex vivo. The residual tumor depth and MRI-based tumor regression grade (TRG) were subjectively assessed and then compared with the pathological findings.

resultsThe ex vivo 9.4T T2WI without fat suppression clearly differentiated tumor tissue, fibrosis and normal rectal wall, which clearly corresponded to the pathologic tissues of the rectal specimens. The TRG could be accurately assessed on ex vivo 9.4T images in 13/15 specimens (86.7%), while in 11/15 specimens (73.3%) on ex vivo 3.0T images.

conclusionEx vivo 9.4T MR imaging clearly displayed the components of rectal wall and proved excellent diagnostic performance for evaluating the treatment response to nCRT, which allow radiologists to understand and then assess more accurately the TRG of LARC after nCRT.

Indexed as

AdenocarcinomaMagnetic Resonance ImagingNeoadjuvant TherapyRectal NeoplasmsAdultAgedChemoradiotherapyFemaleHumansMaleMiddle AgedRectumTreatment Outcomeex vivomagnetic resonance imagingpathological tumor regressionrectal cancer

Identifiers

PMID39087899
PMCPMC11293138

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