Evidence map›Paper›PMID 39087820›Full record

ReviewMass spectrometry reviews

Recent advances in high-resolution traveling wave-based ion mobility separations coupled to mass spectrometry.

Cameron N Naylor, Gabe Nagy

Abstract readReview
In one paragraph

Review in Mass spectrometry reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Chiral Carbohydrate Adducts are Effective for Enantiomeric Ion Mobility Separations.Journal of the American Society for Mass Spectrometry · 2026
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  6. Computational Tools for LC-IMS-MS Data Processing in Metabolomics.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cameron N NaylorDepartment of Chemistry, University of Utah, Salt Lake City, Utah, USA.ORCID http://orcid.org/0000-0002-3426-0367
Gabe NagyDepartment of Chemistry, University of Utah, Salt Lake City, Utah, USA.ORCID http://orcid.org/0000-0001-9007-4422

Funding

A bioanalytical research program to unravel the human milk glycomeR35GM146671 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Gabe Nagy · 2022 to 2026
$1.9M
NIGMS NIH HHS 1R35GM146671-01NIGMS NIH HHS R35 GM146671
6 · The paper itself

Abstract

Recently, ion mobility spectrometry-mass spectrometry (IMS-MS) has become more readily incorporated into various omics-based workflows. These growing applications are due to developments in instrumentation within the last decade that have enabled higher-resolution ion mobility separations. Two such platforms are the cyclic (cIMS) and structures for lossless ion manipulations (SLIM), both of which use traveling wave ion mobility spectrometry (TWIMS). High-resolution separations achieved with these techniques stem from the drastically increased pathlengths, on the order of 10 s of meters to >1 km, in both cIMS-MS and SLIM IMS-MS, respectively. Herein, we highlight recent developments and advances, for the period 2019-2023, in high-resolution traveling wave-based IMS-MS through instrumentation, calibration strategies, hyphenated techniques, and applications. Specifically, we will discuss applications including CCS calculations in multipass IMS-MS separations, coupling of IMS-MS with chromatography, imaging, and cryogenic infrared spectroscopy, and isomeric separations of glycans, lipids, and other small metabolites.

Indexed as

ion mobility spectrometryisomersmass spectrometryseparation science

Identifiers

PMID39087820
PMCPMC11785821

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.