Evidence map›Paper›PMID 39087469›Full record

ArticleThe Journal of clinical investigation2024

Human milk antibodies to global pathogens reveal geographic and interindividual variations in IgA and IgG.

Joseph J Campo, Antti E Seppo, Arlo Z Randall, Jozelyn Pablo, Chris Hung, Andy Teng, Adam D Shandling, Johnathon Truong, Amit Oberai, James Miller and 20 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07615842 (Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07615842 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants

TypeinterventionalSponsorUniversity of VirginiaRan2026 to 2028Enrolled150ConditionsAntibiotic Resistance PreventionArmsAzithromycin
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Joseph J CampoAntigen Discovery Incorporated, Irvine, California, USA.
Antti E SeppoDepartment of Pediatrics, Division of Allergy and Immunology, University of Rochester School of Medicine, Rochester, New York, USA.
Arlo Z RandallAntigen Discovery Incorporated, Irvine, California, USA.
Jozelyn PabloAntigen Discovery Incorporated, Irvine, California, USA.
Chris HungAntigen Discovery Incorporated, Irvine, California, USA.
Andy TengAntigen Discovery Incorporated, Irvine, California, USA.
Adam D ShandlingAntigen Discovery Incorporated, Irvine, California, USA.
Johnathon TruongAntigen Discovery Incorporated, Irvine, California, USA.
Amit OberaiAntigen Discovery Incorporated, Irvine, California, USA.
James MillerDepartment of Pediatrics, Division of Allergy and Immunology, University of Rochester School of Medicine, Rochester, New York, USA.
Najeeha Talat IqbalDepartment of Paediatrics and Child Health, Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
Pablo Peñataro YoriDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Anna Kaarina KukkonenNew Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mikael KuitunenNew Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
L Beryl GutermanHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Shaun K MorrisCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Lisa G PellCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Abdullah Al MahmudNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Girija RamakrishanDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Eva HeinzDepartments of Vector Biology and Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Beth D KirkpatrickVaccine Testing Center and Department of Microbiology and Molecular Genetics, The University of Vermont College of Medicine, Burlington, Vermont, USA.
Abu Sg FaruqueEmerging Infection and Parasitology Laboratory, Division of Infectious Diseases, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Rashidul HaqueEmerging Infection and Parasitology Laboratory, Division of Infectious Diseases, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
R John LooneyDepartment of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester School of Medicine, Rochester, New York, USA.
Margaret N KosekDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Erkki SavilahtiNew Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Saad B OmerPeter O'Donnell Jr. School of Public Health, Dallas, Texas, USA.
Daniel E RothCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
William A PetriDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Kirsi M JärvinenDepartment of Pediatrics, Division of Allergy and Immunology, University of Rochester School of Medicine, Rochester, New York, USA.

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
NIAID NIH HHS R01 AI043596NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

BACKGROUNDThe use of high-throughput technologies has enabled rapid advancement in the knowledge of host immune responses to pathogens. Our objective was to compare the repertoire, protection, and maternal factors associated with human milk antibodies to infectious pathogens in different economic and geographic locations.METHODSUsing multipathogen protein microarrays, 878 milk and 94 paired serum samples collected from 695 women in 5 high and low-to-middle income countries (Bangladesh, Finland, Peru, Pakistan, and the United States) were assessed for specific IgA and IgG antibodies to 1,607 proteins from 30 enteric, respiratory, and bloodborne pathogens.RESULTSThe antibody coverage across enteric and respiratory pathogens was highest in Bangladeshi and Pakistani cohorts and lowest in the U.S. and Finland. While some pathogens induced a dominant IgA response (Campylobacter, Klebsiella, Acinetobacter, Cryptosporidium, and pertussis), others elicited both IgA and IgG antibodies in milk and serum, possibly related to the invasiveness of the infection (Shigella, enteropathogenic E. coli "EPEC", Streptococcus pneumoniae, Staphylococcus aureus, and Group B Streptococcus). Besides the differences between economic regions and decreases in concentrations over time, human milk IgA and IgG antibody concentrations were lower in mothers with high BMI and higher parity, respectively. In Bangladeshi infants, a higher specific IgA concentration in human milk was associated with delayed time to rotavirus infection, implying protective properties of antirotavirus antibodies, whereas a higher IgA antibody concentration was associated with greater incidence of Campylobacter infection.CONCLUSIONThis comprehensive assessment of human milk antibody profiles may be used to guide the development of passive protection strategies against infant morbidity and mortality.FUNDINGBill and Melinda Gates Foundation grant OPP1172222 (to KMJ); Bill and Melinda Gates Foundation grant OPP1066764 funded the MDIG trial (to DER); University of Rochester CTSI and Environmental Health Sciences Center funded the Rochester Lifestyle study (to RJL); and R01 AI043596 funded PROVIDE (to WAP).

Indexed as

Immunoglobulin AImmunoglobulin GMilk, HumanAdultAntibodies, BacterialBangladeshFemaleHumansAntibodies, BacterialImmunoglobulin AImmunoglobulin GAdaptive immunityImmunoglobulinsInfectious disease

Identifiers

PMID39087469
PMCPMC11290967

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.