Evidence map›Paper›PMID 39086990›Full record

ArticleTherapeutic advances in gastroenterology2024

Long-term outcomes and predictors of vedolizumab persistence in ulcerative colitis.

Beatriz Gros, Hannah Ross, Maureen Nwabueze, Nathan Constantine-Cooke, Lauranne A A P Derikx, Mathew Lyons, Claire O'Hare, Colin Noble, Ian D Arnott, Gareth-Rhys Jones and 2 more

Abstract read
In one paragraph

Article in Therapeutic advances in gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Beatriz GrosEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK.ORCID https://orcid.org/0000-0002-5628-313X
Hannah RossEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK.
Maureen NwabuezeEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK.
Nathan Constantine-CookeMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
Lauranne A A P DerikxEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK Inflammatory Bowel Disease Center, Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Mathew LyonsEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK.
Claire O'HareEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK.
Colin NobleEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK.
Ian D ArnottEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK.
Gareth-Rhys JonesEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK.
Charlie W LeesEdinburgh IBD Unit, Western General Hospital, NHS Lothian, Crewe Road, Edinburgh EH4 2XU, UK.
Nikolas PlevrisEdinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Background: Long-term vedolizumab (VDZ) outcomes in real-world cohorts have been largely limited to 1-year follow-up, with few bio-naïve patients or objective markers of inflammation assessed. Objectives: We aimed to assess factors affecting VDZ persistence including clinical, biochemical and faecal biomarker remission at 1, 3 and 5 years. Design: We performed a retrospective, observational, cohort study. Methods: All adult inflammatory bowel disease (IBD) patients who had received VDZ induction for ulcerative colitis (UC)/IBD-unclassified (IBDU) were included. Baseline phenotype and follow-up data were collected Results: We included 290 patients [UC Conclusion: VDZ effectiveness appears enduring with favourable long-term safety profile. VDZ persistence was influenced by previous exposure to biologics/small molecules, disease distribution and steroid use at baseline in our study.

Indexed as

real-world evidenceulcerative colitisvedolizumab

Identifiers

PMID39086990
PMCPMC11289824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.