Evidence map›Paper›PMID 39086641›Full record

ReviewWorld journal of gastroenterology2024

Photo-activated microtubule targeting drugs: Advancing therapies for colorectal cancer.

Naresh Singh, Samantha Sharma

Abstract readReview
In one paragraph

Review in World journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Naresh SinghDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Samantha SharmaDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States. samshar@iu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the years immunotherapy has demonstrably improved the field of cancer treatment. However, achieving long-term survival for colorectal cancer (CRC) patients remains a significant unmet need. Combination immunotherapies incorporating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative benefit. Nevertheless, substantial gaps remain in the current therapeutic armamentarium for CRC. In recent years, there has been a surge of interest in exploring novel treatment strategies, including the application of light-activated drugs in conjunction with optical devices. This approach holds promise for achieving localized and targeted delivery of cytotoxic agents, such as microtubule-targeting drugs, directly to cancerous cells within the colon.

Indexed as

Colorectal NeoplasmsMicrotubulesAntineoplastic AgentsDrug Delivery SystemsHumansImmunotherapyMolecular Targeted TherapyPhotochemotherapyPhotosensitizing AgentsTubulin ModulatorsAntineoplastic AgentsPhotosensitizing AgentsTubulin ModulatorsColorectal cancerImmunotherapiesMicrotubulePhoto pharmacologyTherapy

Identifiers

PMID39086641
PMCPMC11287401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.