Evidence map›Paper›PMID 39086605›Full record

ArticleFrontiers in cellular and infection microbiology2024

Methylome-wide analysis in systemic microbial-induced experimental periodontal disease in mice with different susceptibility.

Cristhiam de Jesus Hernandez Martinez, Joseph Glessner, Livia Sertori Finoti, Pedro Felix Silva, Michel Messora, Ricardo Della Coletta, Hakon Hakonarson, Daniela Bazan Palioto

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. In Vitro Infection of Human Macrophages withInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cristhiam de Jesus Hernandez MartinezDepartment of Oral & Maxillofacial Surgery and Periodontology, Ribeirão Preto Dental School, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
Joseph GlessnerThe Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Livia Sertori FinotiLaboratory of Rebecca Ahrens-Nicklas,Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Pedro Felix SilvaDepartment of Oral & Maxillofacial Surgery and Periodontology, Ribeirão Preto Dental School, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
Michel MessoraDepartment of Oral & Maxillofacial Surgery and Periodontology, Ribeirão Preto Dental School, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
Ricardo Della ColettaDepartment of Oral Diagnosis and Graduate Program in Oral Biology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Hakon HakonarsonThe Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Daniela Bazan PaliotoDepartment of Oral & Maxillofacial Surgery and Periodontology, Ribeirão Preto Dental School, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The study delved into the epigenetic factors associated with periodontal disease in two lineages of mice, namely C57bl/6 and Balb/c. Its primary objective was to elucidate alterations in the methylome of mice with distinct genetic backgrounds following systemic microbial challenge, employing high-throughput DNA methylation analysis as the investigative tool. Methods: Results: Of particular significance was the distinct methylation profile observed within the Conclusion: The differential DNA methylation patterns observed between C57bl/6 and Balb/c mouse lines suggest that epigenetic factors contribute to the variations in disease susceptibility. The identified differentially methylated regions associated with immune regulation and inflammatory response provide potential targets for further investigation. These findings emphasize the importance of considering epigenetic mechanisms in the development and progression of periodontitis.

Indexed as

Disease Models, AnimalDNA MethylationMice, Inbred BALB CMice, Inbred C57BLPorphyromonas gingivalisAnimalsBacteroidaceae InfectionsDisease SusceptibilityEpigenesis, GeneticEpigenomeMicePeriodontal DiseasesPeriodontitisdifferential methylome analysisDNA methylationmethylomemouse modelsperiodontal diseasePorphyromonas gingivalis

Identifiers

PMID39086605
PMCPMC11289848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.