ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Diagnostic performance of light reflex pupillometry in Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Simultaneous Analysis of Microsaccades and Pupil Size Variations in Age-Related Cognitive Impairment Using Eye-Tracking Technology.Journal of eye movement research · 2026Article
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Prognostic value of light reflex pupillometry in Alzheimer's disease - a longitudinal cohort study.Alzheimer's research & therapy · 2025Article
- Alzheimer's disease digital biomarkers multidimensional landscape and AI model scoping review.NPJ digital medicine · 2025Article
- Diagnostic performance of actigraphy in Alzheimer's disease using a machine learning classifier - a cross-sectional memory clinic study.Alzheimer's research & therapy · 2025Article
- Probing locus coeruleus functional network in healthy aging and its association with Alzheimer's disease biomarkers using pupillometry.Alzheimer's research & therapy · 2025Article
- Smartphone-Based Pupillometry Using Machine Learning for the Diagnosis of Sports-Related Concussion.Diagnostics (Basel, Switzerland) · 2024Article
- Diagnostic performance of light reflex pupillometry in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Sensory changes in preclinical, prodromal, and clinical Alzheimer's disease and related dementias.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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6 authors.
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Abstract
Easily applied diagnostic tools such as digital biomarkers for Alzheimer's disease (AD) are urgently needed due to the recent approval of disease-modifying therapies. We aimed to determine the diagnostic performance of hand-held, quantitative light reflex pupillometry (qLRP) in patients with AD in a proof-of-concept, cross-sectional study. Participants underwent qLRP at a university memory clinic from August 2022 to October 2023. We fitted multivariable logistic regression models with qLRP, sex, and age as predictors evaluated with area under the receiver operating characteristics curve (AUROC). In total, 107 patients with AD, 44 patients with mixed AD and vascular cognitive dysfunction (VCD), 53 patients with dementia with Lewy bodies (DLB), and 50 healthy controls (HCs) were included. Our diagnostic models showed similar discriminatory ability (AUROC range 0.74-0.81) when distinguishing patients with AD from HCs and other dementias. The qLRP seems promising as a bedside digital biomarker to aid in diagnosing AD. Highlights: We demonstrated the diagnostic performance of qLRP in Alzheimer's disease.The diagnostic models were robust in sensitivity analyses.qLRP may assist in the bedside diagnostic evaluation of Alzheimer's disease.
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