Evidence map›Paper›PMID 39086435›Full record

ReviewFrontiers in molecular medicine2024

Current advances in experimental and computational approaches to enhance CAR T cell manufacturing protocols and improve clinical efficacy.

Alfredo S Colina, Viren Shah, Ravi K Shah, Tanya Kozlik, Ranjan K Dash, Scott Terhune, Anthony E Zamora

Abstract readReview
In one paragraph

Review in Frontiers in molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alfredo S Colina *Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.
Viren Shah *Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, Milwaukee, WI, United States.
Ravi K ShahDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Tanya KozlikDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.
Ranjan K DashDepartment of Biomedical Engineering, Medical College of Wisconsin and Marquette University, Milwaukee, WI, United States.
Scott TerhuneDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.
Anthony E ZamoraDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the FDA's approval of chimeric antigen receptor (CAR) T cells in 2017, significant improvements have been made in the design of chimeric antigen receptor constructs and in the manufacturing of CAR T cell therapies resulting in increased

Indexed as

CAR T cellchimeric antigen receptor T cellscomputational modelingfunctional assaysmanufacturing

Identifiers

PMID39086435
PMCPMC11285593

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.