ArticleNature cardiovascular research2024
Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways.
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Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
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Who cites it
36 citing papers in PubMed.
- Patient-Derived 3D Heart-On-a-Chip Model of Dilated Cardiomyopathy With Embedded Bead-Based Mapping of Tissue Contractility.Advanced healthcare materials · 2026Article
- Immunoids: Building immunocompetent organoids from human pluripotent stem cells.Cell stem cell · 2026Review
- The Role of Glucose Metabolism inInternational journal of molecular sciences · 2026Article
- The Immune System as a Proarrhythmic Mediator: A Novel Paradigm for the Development of New Antiarrhythmic Therapy.The Canadian journal of cardiology · 2026Review
- Heart-on-a-chip and vasculature-on-a-chip platforms as models of cardiovascular disease.Nature reviews. Cardiology · 2026Review
- Myocardial Immune Niches in Homeostasis and Inflammation.Immunological reviews · 2026Review
- Human Hematopoietic Stem Cells Enhance Maturational Differentiation of hiPSC-Derived Cardiomyocytes on Xeno-Free MatriClone-Plastic via EGFR/MAPK/ERK Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Regenerative macrophages enhance stem cell-derived β cell function and engraftment.Science advances · 2026Article
- Mitochondria Clearance Enables Macrophage-Driven Maturation of iPSC-Derived Cardiomyocyte Metabolism.Cellular and molecular bioengineering · 2026Article
- Mapping the miRNA landscape of primitive macrophage extracellular vesicles highlights their pro-vasculogenic effects in engineered human cardiac tissue.APL bioengineering · 2026Article
- Macrophage Efferocytosis in Heart.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Review
- Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components.Nature communications · 2026Article
- Protocol to generate immunocompetent human heart-macrophage assembloids for the study of immune-cardiac interactions.STAR protocols · 2026Article
- Cardiac Macrophages and Fibroblasts Modulate Atrial Fibrillation Maintenance.Circulation research · 2026Article
- Review
- A Human-Based Skin-Lymphoreticular Model-on-Chip to Emulate Inflammatory Skin Conditions.Advanced healthcare materials · 2026Article
- Ventricular assist device unloading reverses microvascular senescence in single ventricle disease.Nature cardiovascular research · 2026Article
- Development and modeling of cardiac autonomic innervation.Nature cardiovascular research · 2025Review
- Review
Corrections and comments
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Authors and funding
32 authors.
Homaira HamidzadaToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Simon Pascual-GilToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Qinghua WuInstitute of Biomedical Engineering, University of Toronto, Toronto, ON.
Gregory M KentMcEwen Stem Cell Institute, University Health Network, Toronto, ON.
Stéphane MasséThe Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital, Toronto, ON.
Crystal KantoresToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Uros KuzmanovDepartment of Physiology, University of Toronto, Toronto, ON.
M Juliana Gomez-GarciaInstitute of Biomedical Engineering, University of Toronto, Toronto, ON.
Naimeh RafatianInstitute of Biomedical Engineering, University of Toronto, Toronto, ON.
Renée A GormanDepartment of Biology, York University, Toronto, ON.
Marianne WauchopDepartment of Biology, York University, Toronto, ON.
Wenliang ChenScientific Research Center, the Second Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, 524023, China.
Shira LandauInstitute of Biomedical Engineering, University of Toronto, Toronto, ON.
Tasnia SubhaThe Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital, Toronto, ON.
Michael H AtkinsMcEwen Stem Cell Institute, University Health Network, Toronto, ON.
Yimu ZhaoToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Erika BeroncalDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON.
Ian FernandesMcEwen Stem Cell Institute, University Health Network, Toronto, ON.
Jared NanthakumarToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Shabana VohraToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Erika Y WangDavid H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, United States.
Tamilla Valdman SadikovMcEwen Stem Cell Institute, University Health Network, Toronto, ON.
Babak RazaniVascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, United States.
Tracy L McGahaDepartment of Immunology, University of Toronto, Toronto, ON.
Ana C AndreazzaDepartment of Psychiatry, University of Toronto, Toronto, ON.
Anthony GramoliniToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Peter H BackxToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Kumaraswamy NanthakumarThe Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital, Toronto, ON.
Michael A LaflammeMcEwen Stem Cell Institute, University Health Network, Toronto, ON.
Gordon KellerMcEwen Stem Cell Institute, University Health Network, Toronto, ON.
Milica RadisicToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Slava EpelmanToronto General Hospital Research Institute, University Health Network, Toronto, ON.
Funding
Engineering Vascularized Cardiac MuscleR01HL076485 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Gordana Vunjak-Novakovic · 2005 to 2026
$9.2MTHE ROLE OF MACROPHAGE LYSOSOMAL BIOGENESIS IN ATHEROSCLEROSISR01HL125838 · NHLBI · WASHINGTON UNIVERSITY · PI RAZANI, BABAK · 2015 to 2025
$4.6MDissecting the Impact of Dietary Protein on Macrophage mTOR Signaling and AtherosclerosisR01HL159461 · NHLBI · WASHINGTON UNIVERSITY · PI Bettina Mittendorfer, Babak Razani · 2022 to 2026
$3.3MHarnessing macrophage lysosomal lipid metabolism in obesity-associated diseasesR01DK131188 · NIDDK · WASHINGTON UNIVERSITY · PI MITTENDORFER, BETTINA, RAZANI, BABAK · 2022 to 2025
$2.6MREGULATION OF MONOCYTE RECRUITMENT INTO THE ISCHEMIC MYOCARDIUM BY THE ACE2 AXISK08HL112826 · NHLBI · WASHINGTON UNIVERSITY · PI EPELMAN, SLAVA · 2012 to 2014
$339kNHLBI NIH HHS K08 HL112826NHLBI NIH HHS R01 HL076485NHLBI NIH HHS R01 HL125838NHLBI NIH HHS R01 HL159461NIDDK NIH HHS R01 DK131188
Abstract
Yolk sac macrophages are the first to seed the developing heart, however we have no understanding of their roles in human heart development and function due to a lack of accessible tissue. Here, we bridge this gap by differentiating human embryonic stem cells (hESCs) into primitive LYVE1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.