ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024
Frailty Status, Sedentary Behaviors, and Risk of Incident Bone Fractures.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characteristics of fragility hip fracture-related falls in the older adults: A systematic review.The journal of nutrition, health & aging · 2024Pooled it
- Dynamic frailty trajectories and risk of age-related macular degeneration: a prospective cohort study in UK Biobank.GeroScience · 2026Article
- Article
- Machine learning derived abdominal aortic calcification is associated with physical frailty in community-dwelling adults: the UK Biobank Imaging Study.GeroScience · 2026Article
- Joint risk factor within target range and hazard of premature mortality in people with obesity.Scientific reports · 2026Article
- Targeting the PINK1/Parkin-FNDC5 pathway: a novel mechanism of icariin in regulating muscle-bone metabolic coupling in osteosarcopenia.Journal of translational medicine · 2026Article
- Sedentary Lifestyle and Estimated Fracture Risk in the Elderly: A Cross-Sectional Study.Cureus · 2026Article
- Beyond bone density: toward an integrated bone- muscle-function framework for fragility fracture prevention.Frontiers in medicine · 2026Article
- Article
- Activity Intensity and All-Cause Mortality Following Fall Injury Among Older Adults: Results from a 12-Year National Survey.Healthcare (Basel, Switzerland) · 2025Article
- Hip Fracture as a Systemic Disease in Older Adults: A Narrative Review on Multisystem Implications and Management.Medical sciences (Basel, Switzerland) · 2025Review
- Machine learning approaches to predict hip fracture incidence: insights from the CHARLS dataset.Frontiers in public health · 2025Article
- The potential association between sedentary behaviors and risk of temporomandibular disorders: evidence from Mendelian randomization analysis.Journal of oral & facial pain and headache · 2024Article
- The Therapeutic Management of Chemical and Herbal Medications on Uric Acid Levels and Gout: Modern and Traditional Wisdom.Pharmaceuticals (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe associations of physical pre-frailty and frailty with bone fractures and the modified effect of sedentary lifestyle remain uncertain. This study was performed to explore the association of physical pre-frailty and frailty with risk of incident bone fractures, and test the modification effects of sedentary lifestyle and other risk factors.
methodsThis cohort study included 413 630 participants without bone fractures at baseline in the UK Biobank study between 2006 and 2010 and followed up to 2021. The mean age of the participants was 56.5 years. A total of 224 351 (54.2%) enrolled participants were female and 376 053 (90.9%) included participants were White. Three Cox regression models were constructed to analyze the association of pre-frailty and frailty with total fractures, hip fractures, vertebrae fractures, and other fractures.
resultsAs compared with the physical nonfrailty group, the multivariate-adjusted hazard ratios were 1.17 (95% confidence interval [CI]: 1.14-1.21) and 1.63 (95% CI: 1.53-1.74) for the physical pre-frailty group and frailty group, respectively (p-trend < .001). In addition, we found that sedentary behavior time significantly accentuated the associations of physical pre-frailty and frailty with total fractures (p-interaction <.001), hip fractures (p-interaction = .013), and other fractures (p-interaction <.001).
conclusionsOur results indicate that physical pre-frailty and frailty are related to higher risks of bone fractures; such association was more pronounced among those with longer sedentary behavior time.
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