ArticleBJPsych open2024
Identifying digital biomarkers of illness activity and treatment response in bipolar disorder with a novel wearable device (TIMEBASE): protocol for a pragmatic observational clinical study.
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Article in BJPsych open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3citing papers in PubMed, 1 pooled it
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Boulevard of broken rhythms: A systematic review and meta-analysis on the relationship between sleep disturbances and suicidal behavior in bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Digital tools for assessing bipolar disorder: A scoping review of the current landscape.Neuroscience applied · 2026Article
- Automated Speech Analysis in Bipolar Disorder: The CALIBER Study Protocol and Preliminary Results.Journal of clinical medicine · 2024Article
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Authors and funding
33 authors.
Gerard AnmellaDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-6798-4054
Filippo CorponiSchool of Informatics, University of Edinburgh, UK.ORCID https://orcid.org/0000-0002-6807-0617
Bryan M LiSchool of Informatics, University of Edinburgh, UK.ORCID https://orcid.org/0000-0003-3144-4838
Ariadna MasDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-8738-8655
Marina GarrigaDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0001-7312-4969
Miriam SanabraDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0003-2206-2264
Isabella PacchiarottiDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-7822-0367
Marc ValentíDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-9783-6220
Iria GrandeDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-0137-0666
Antoni BenabarreDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0001-8814-2246
Anna Giménez-PalomoDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-9474-6473
Isabel AgasiDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain.ORCID https://orcid.org/0000-0002-0381-7951
Anna BastidasDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0001-8240-1438
Myriam CaveroDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-5283-5523
Miquel BioqueDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Barcelona Clinic Schizophrenia Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID https://orcid.org/0000-0001-6887-7149
Clemente García-RizoDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Barcelona Clinic Schizophrenia Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID https://orcid.org/0000-0002-4855-1608
Santiago MaderoDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Barcelona Clinic Schizophrenia Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID https://orcid.org/0000-0002-1123-4211
Néstor ArbeloDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Barcelona Clinic Schizophrenia Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID https://orcid.org/0000-0002-2630-3259
Andrea MurruDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0001-6320-4420
Silvia AmorettiDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0001-6017-2734
Anabel Martínez-AranDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-0623-6263
Victoria RuizDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain.ORCID https://orcid.org/0000-0001-9198-4663
Yudit RivasDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain.ORCID https://orcid.org/0009-0004-1297-3843
Giovanna FicoDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0003-1785-7126
Michele De PriscoDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-2032-1181
Vincenzo OlivaDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-5961-6032
Aleix SolanesInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID https://orcid.org/0000-0002-2491-200X
Joaquim RaduaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Early Psychosis: Interventions & Clinical Detection (EPIC) Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; and Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden.ORCID https://orcid.org/0000-0003-1240-5438
Ludovic SamalinInstitut Pascal (UMR 6602), Department of Psychiatry, CHU Clermont-Ferrand, University of Clermont Auvergne, CNRS, Clermont Auvergne INP, France; and Association Française de Psychiatrie Biologique et Neuropsychopharmacologie (AFPBN), Saint Germain en Laye, France.ORCID https://orcid.org/0000-0003-0740-4019
Allan H YoungCentre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.ORCID https://orcid.org/0000-0003-2291-6952
Antonio VergariSchool of Informatics, University of Edinburgh, UK.ORCID https://orcid.org/0000-0003-0036-5678
Eduard VietaDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-0548-0053
Diego Hidalgo-MazzeiDigital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.ORCID https://orcid.org/0000-0002-2693-6849
Funding
Instituto de Salud Carlos III PI21/00340Milken Family Foundation PI046998
Abstract
backgroundBipolar disorder is highly prevalent and consists of biphasic recurrent mood episodes of mania and depression, which translate into altered mood, sleep and activity alongside their physiological expressions.
aimsThe IdenTifying dIgital bioMarkers of illnEss activity and treatment response in BipolAr diSordEr with a novel wearable device (TIMEBASE) project aims to identify digital biomarkers of illness activity and treatment response in bipolar disorder.
methodWe designed a longitudinal observational study including 84 individuals. Group A comprises people with acute episode of mania (
resultsRecruitment is ongoing.
conclusionsThis project should contribute to understanding the pathophysiology of affective disorders. The potential digital biomarkers of illness activity and treatment response in bipolar disorder could be implemented in a real-world clinical setting for clinical monitoring and identification of prodromal symptoms. This would allow early intervention and prevention of affective relapses, as well as personalisation of treatment.
Indexed as
Bipolar disorderdepressiondigital biomarkersmaniaphysiological data
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