Evidence map›Paper›PMID 39086095›Full record

ArticleCutaneous and ocular toxicology2024

Safety and tolerability of pooled human immune globulins after topical ophthalmic administration in New Zealand White rabbits.

Simon Kaja, Sana Iqbal, Berta Pons Lopez, Sergio Molina Zaragoza, Christine Mun, Michael T Flavin, Sandeep Jain

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cutaneous and ocular toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simon KajaOphthalmology, Loyola University Chicago, Maywood, Illinois, USA.
Sana IqbalProgram in Molecular Pharmacology and Therapeutics, Loyola University Chicago, Maywood, Illinois, USA.
Berta Pons LopezGrifols Scientific Innovation Office, Parets del Vallès, Spain.
Sergio Molina ZaragozaGrifols Scientific Innovation Office, Parets del Vallès, Spain.
Christine MunEye and Ear Infirmary, University of IL at Chicago, Chicago, Illinois, USA.
Michael T FlavinEye and Ear Infirmary, University of IL at Chicago, Chicago, Illinois, USA.
Sandeep JainEye and Ear Infirmary, University of IL at Chicago, Chicago, Illinois, USA.

Funding

Immunotherapy for Ocular Surface DiseasesR24EY032440 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JAIN, SANDEEP · 2021 to 2025
$8.3M
NEI NIH HHS R24 EY032440
6 · The paper itself

Abstract

purposeTo evaluate the safety and tolerability of pooled human immune globulins, Flebogamma

methodsMale NZW rabbits were used in this study. In the acute single dose tolerability study, rabbits (n = 12) received a single topical dose of Flebogamma

resultsIn the acute single dose study, mild hyperaemia was observed in 1 out of 4 eyes at each 4 h and 24 h post-instillation of Flebogamma

conclusionsFlebogamma

Indexed as

Administration, OphthalmicOphthalmic SolutionsAdministration, TopicalAnimalsEyeHumansMaleRabbitsOphthalmic Solutionsdrug repurposingdry eyeFlebogamma®Ocular ToxicologyPooled human immune globulinstolerability

Identifiers

PMID39086095
PMCPMC11383756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.