Evidence map›Paper›PMID 39085909›Full record

ArticlePhysiological reports2024

Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex-dependent manner.

Avigail Ehrlich, Graziano Pelli, Robert Pick, Linda Clochard, Filippo Molica, Brenda R Kwak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Avigail EhrlichDepartment of Pathology and Immunology (PATIM), University of Geneva, Geneva, Switzerland.
Graziano PelliDepartment of Pathology and Immunology (PATIM), University of Geneva, Geneva, Switzerland.
Robert PickDepartment of Pathology and Immunology (PATIM), University of Geneva, Geneva, Switzerland.
Linda ClochardDepartment of Pathology and Immunology (PATIM), University of Geneva, Geneva, Switzerland.
Filippo MolicaDepartment of Pathology and Immunology (PATIM), University of Geneva, Geneva, Switzerland.
Brenda R KwakDepartment of Pathology and Immunology (PATIM), University of Geneva, Geneva, Switzerland.ORCID 0000-0003-0015-0044

Funding

Gabbiani Fund N/ASwiss National Science Foundation 310030_182573
6 · The paper itself

Abstract

The lymphatic network of capillaries and collecting vessels ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells. Pannexin1 (Panx1) channels allow for the passage of ions and small metabolites between the cytosol and extracellular environment. Panx1 channels regulate the pathophysiological function of several tissues in a sex-dependent manner. Here, we studied the role of Panx1 in lymphatic function, and potential sex-dependent differences therein, in Prox1-CreER

Indexed as

ConnexinsEndothelium, LymphaticNerve Tissue ProteinsAnimalsEndothelial CellsFemaleLymphatic VesselsMaleMiceMice, Inbred C57BLSex CharacteristicsConnexinsNerve Tissue ProteinsPanx1 protein, mouselymphatic endothelial cellslymphatic functionpannexin1sex differences

Identifiers

PMID39085909
PMCPMC11291012

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.