ArticleBMC oral health2024
Comparative analysis of microbiome in coronal and root caries.
Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- DNA and RNA-based amplicon sequencing of paired supragingival and dentin lesion plaque in children with severe early childhood caries.International journal of oral science · 2026Article
- Mechanisms of caries induced by sugars: a narratives review from microbial metabolism to oral ecological imbalance and public health strategies for caries prevention.Frontiers in cellular and infection microbiology · 2026Review
- Feasibility of salivary lipid screening for caries biomarkers in young adults.BMC oral health · 2025Article
- Impact of Different Regimens of Fluoridated Dentifrice Application on the pH and Inorganic Composition in an Oral Microcosm Biofilm Model.Microorganisms · 2025Article
- Tooth-surface plaque microbiome and different levels of oral disease burden among dentate older adults living in long-term care.Journal of oral microbiology · 2025Article
- Comparison of the effects of clear aligners and fixed appliances on the oral microbiota and reactive oxygen species: a prospective study.Frontiers in cellular and infection microbiology · 2025Article
- Specialty-Oriented Graduate Education in Laboratory Medicine at Oral Specialty Hospitals: A Practice-Based Descriptive Analysis.Journal of medical education and curricular developmentArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe global rise in the elderly population has increased the prevalence of root caries. Streptococcus mutans, Lactobacilli and Actinomyces are considered the primary pathogens of dental caries in culture-based studies. This study aimed to investigate bacterial profiles in coronal and root caries lesions and determine the association of specific bacterial genera at each site.
methodsDentine samples from carious lesions were collected from 22 extracted teeth using an excavator. Microbial DNA was extracted from the samples using a protocol developed for this study. 16S rRNA gene amplicon sequencing was employed for microbial analysis. PCR amplification targeted the V3-V4 region of the bacterial 16S rRNA, and the amplicon sequencing used an Illumina MiSeq system (2 × 300 bp paired-end reads). Statistical analysis was performed by the Phyloseq and DESeq2 packages in R.
resultsIn coronal caries, Olsenella, Lactobacillus and Prevotella were the most prevalent genera, comprising approximately 70% of the microbiome community. In the root caries, however, although Olsenella, Prevotella and Lactobacillus remained the dominant genera, they accounted for only half of the microbiome community. This study identified significant differences in alpha diversity indices between the coronal and root caries. LEfSE analysis revealed several unique genera in each caries lesion.
conclusionThe microbiome of root caries lesions was richer and more complex than the coronal caries microbiota. The results suggest that lesion-related variations in the oral microflora may be detected in carious dentine.
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